Dong Fang

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Pediatric brainstem gliomas often harbor oncogenic K27M mutation of histone H3.3. Here we show that GSKJ4 pharmacologic inhibition of K27 demethylase JMJD3 increases cellular H3K27 methylation in K27M tumor cells and demonstrate potent antitumor activity both in vitro against K27M cells and in vivo against K27M xenografts. Our results demonstrate that(More)
—In this paper, we propose a new downlink non-orthogonal multiuser superposition transmission scheme for future 5G cellular networks, which we refer to as the lattice partition multiple access (LPMA). In this proposed design, the base station transmits multilevel lattice codes for multiple users. Each user's code level corresponds to a distinct prime and is(More)