Dondapati Chowdary

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A DNA cross-link adduct of the antitumor agent mitomycin C (MC) to DNA has been isolated and characterized; the results provide direct proof for bifunctional alkylation of DNA by MC. Exposure of MC to Micrococcus luteus DNA under reductive conditions and subsequent nuclease digestion yielded adducts formed between MC and deoxyguanosine residues. In addition(More)
BACKGROUND Several studies have demonstrated the value of DNA methylation in urine-based assays for prostate cancer diagnosis. However, a multicenter validation with a clinical prototype has not been published. METHODS We developed a multiplexed, quantitative methylation-specific polymerase chain reaction (MSP) assay consisting of 3 methylation markers,(More)
Extra High Voltage and Ultra High Voltage porcelain solid core post insulators for use in up to 1200kV AC systems are being manufactured by various insulator manufacturers in India. One application is to use as bus support insulator in 1200kV substations. The post insulators shall have superior corona free performance for reliable and safe substation(More)
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