Donald Wlodkowic

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The diversity of cell populations is regulated by extracellular and intracellular variability. The latter includes genetic, epigenetic and stochastic variability, all contributing to the experimentally observed heterogeneity in response to external death-inducing stimuli. Studies of sources and regulation of variability in commitment to apoptotic cancer(More)
Zebrafish (Danio rerio) has recently emerged as a powerful experimental model in drug discovery and environmental toxicology. Drug discovery screens performed on zebrafish embryos mirror with a high level of accuracy the tests usually performed on mammalian animal models, and fish embryo toxicity assay (FET) is one of the most promising alternative(More)
This paper presents a high level systematic design approach for a distinctive type of application, automated Bio Cybernetic Systems (BCS), which enable experiments to be performed autonomously on live organisms in a Lab-on-Chip platform. The system integrates micro-electro-mechanical, microfluidics and embedded computing technologies into a fully Automated(More)
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