Donald Snyder

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We utilized the methods of comparative psychology and of ethology to assess the effects of frontal lesions on species-specific aversive and aggressive behaviors in rhesus monkeys. Removal of orbital frontal (OF) cortex enhanced aversive reactions and reduced aggressive reactions in several threatening situations, including a social colony. The deficit in(More)
Monkeys with orbital frontal ablation, compared with sham-operated controls, showed enhancement of oral tendencies toward nonfood items. Further, unlike the controls, they persistently performed an instrumental response for one of these nonfood items. On the other hand, the lesioned monkeys did not show altered preferences for food versus nonfood items.(More)
Recent research suggests that a significant relationship between frontal brain asymmetry (FBA) and affective style can be documented in women with 1-measurement occasion. The purpose of this study was to determine whether this finding is generalizable to men. Resting electroencephalogram (EEG) activity was recorded from male adults during 5 60-s baselines(More)
BACKGROUND To assess the response of patients with soft tissue sarcoma (STS) to the combination of docetaxel, bevacizumab, and gemcitabine. Vascular endothelial growth factor (VEGF)-A levels and expression of VEGF-A and VEGF receptors 1 and 2 were evaluated. PATIENTS AND METHODS Thirty-eight chemotherapy-naive patients with STS were enrolled. A(More)
PURPOSE Halofuginone (tempostatin) is a synthetic derivative of a quinazolinone alkaloid showing anti-angiogenic, anti-metastatic and anti-proliferative effects in preclinical studies. The objectives of this phase I study were to assess the dose-limiting toxicities (DLTs), to determine the maximum tolerated dose (MTD) and to study the pharmacokinetics (PKs)(More)
Pediatricians caring for sexually active female adolescents and young adults need to be aware of the history, symptoms, and signs of an ectopic pregnancy. A thorough history and physical examination, including the pelvic examination, as well as specific diagnostic tests such as repeated quantitative hCG measurements, and ultrasonography when indicated, are(More)