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Identification and characterization of nuclease-stabilized RNA molecules that bind human prostate cancer cells via the prostate-specific membrane antigen.

• Shawn E Lupold, Brian J. Hicke, Yun Lian Lin, Donald S. Coffey
• Cancer research
• 2002

We have identified two synthetic oligonucleotides (aptamers) that bind to prostate cancer cells,with low nanomolar affinity, via the extracellular portion of the prostate-specificmembrane antigen… (More)

The development of human benign prostatic hyperplasia with age.

• Stephen J. Berry, Donald S. Coffey, Patrick Walsh, Larry L. Ewing
• The Journal of urology
• 1984

In this study we report the prevalence and growth rate of human benign prostatic hyperplasia with age by combining and analyzing data from 10 independent studies containing more than 1,000 prostates.… (More)

DNA packaging and organization in mammalian spermatozoa: comparison with somatic cells.

• W Steven Ward, Donald S. Coffey
• Biology of reproduction
• 1991

Mammalian sperm DNA is the most tightly compacted eukaryotic DNA, being at least sixfold more highly condensed than the DNA in mitotic chromosomes. To achieve this high degree of packaging, sperm DNA… (More)

Supercoiled loops and eucaryotic DNA replication

• Bert Vogelstein, Drew Mark Pardoll, Donald S. Coffey
• Cell
• 1980

A structural analysis of the role of the nuclear matrix and DNA loops in the organization of the nucleus and chromosome.

• Donald S. Coffey
• Journal of cell science. Supplement
• 1984

The interphase nucleus is characterized by a nuclear matrix structure that forms a residual scaffolding composed of approximately 10% of the total nuclear proteins. The nuclear matrix contains… (More)

The epidemiology of prostate cancer in Jamaica.

• Fred Glover, Donald S. Coffey, +6 authors Patrick Walsh
• The Journal of urology
• 1998

PURPOSE Before this study, the highest reported incidence of prostate cancer in the world was thought to be among United States black men. The age adjusted rates in 1992 for United States black and… (More)

The prostate: an increasing medical problem.

• Herbert Ballentine Carter, Donald S. Coffey
• The Prostate
• 1990

The prostate gland is the major site of medical problems in the U.S. male. Surgery for benign prostatic hyperplasia is the most common surgical procedure performed in males, and the total cost for… (More)

Stem cell features of benign and malignant prostate epithelial cells.

• Angelo M De Marzo, William Andrew Nelson, Alan K Meeker, Donald S. Coffey
• The Journal of urology
• 1998

PURPOSE We present a new hypothesis suggesting that the different malignant potential of benign prostatic hyperplasia (BPH) and high grade prostatic intraepithelial neoplasia may be explained by… (More)

The role of androgens and estrogens in the pathogenesis of experimental nonbacterial prostatitis.

• Michael James Naslund, John D. Strandberg, Donald S. Coffey
• The Journal of urology
• 1988

The etiology and pathogenesis of nonbacterial prostatitis remains unclear. This study provides evidence that genetic background, advancing age, and hormonal imbalance are important etiologic factors… (More)

High mobility group protein I(Y): a candidate architectural protein for chromosomal rearrangements in prostate cancer cells.

• Natsuki Takaha, Anita L. Hawkins, Constance A. Griffin, William B Isaacs, Donald S. Coffey
• Cancer research
• 2002

The extent of chromosomal rearrangements correlates positively with the level of expression of the nuclear matrix high mobility group (HMG) proteins HMGI(Y) when tested in three human prostate cancer… (More)

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