Donald R. Stanski

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Simultaneous modeling of pharmacokinetics and pharmacodynamics: application to d-tubocurarine.

Lewis B. Sheiner, Donald R. Stanski, S. Vožeh, Ronald Douglas Miller, Jonathan Ham
Clinical pharmacology and therapeutics
1979

We propose a model of drug pharmacodynamic response that when integrated with a pharmacokinetic model allows characterization of the temporal aspects of pharmacodynamics as well as the… (More)

Decreased fentanyl and alfentanil dose requirements with age. A simultaneous pharmacokinetic and pharmacodynamic evaluation.

James C. Scott, Donald R. Stanski
The Journal of pharmacology and experimental…
1987

The effect of increasing age on the dose of fentanyl or alfentanil required to produce the same electroencephalographic (EEG) stage was studied in adult male patients. The pharmacokinetic and… (More)

A comparison of spectral edge, delta power, and bispectral index as EEG measures of alfentanil, propofol, and midazolam drug effect.

V Billard, Pedro L. Gambús, Nidal Chamoun, Donald R. Stanski, Steven L. Shafer
Clinical pharmacology and therapeutics
1997

BACKGROUND The effects of anesthetic drugs on electroencephalograms (EEG) have been studied to develop the EEG as a measure of anesthetic depth. Bispectral analysis is a new quantitative technique… (More)

A three-step approach combining bayesian regression and NONMEM population analysis: Application to midazolam

Pierre O. Maitre, Michael Buehrer, Dorothy Thomson, Donald R. Stanski
Journal of Pharmacokinetics and Biopharmaceutics
1991

NONMEM, the only available supported program for population pharmacokinetic analysis, does not provide the analyst with individual subject parameter estimates. As a result, the relationship between… (More)

Simultaneous Modeling of Pharmacokinetics and Pharmacodynamics

Lewis B. Sheiner, Donald R. Stanski, S. Vožeh, Ronald Douglas Miller, J. Ham
1980

Comparative pharmacology of the ketamine isomers. Studies in volunteers.

Paul F. White, Jürgen Schüttler, Audrey Shafer, Donald R. Stanski, Yukio Horai, Anthony J. Trevor
British journal of anaesthesia
1985

The clinical and electroencephalographic (EEG) effects of the individual ketamine isomers were compared with the racemic mixture in five volunteers who received each drug on a separate occasion.… (More)

Absorption and bioavailability of oral transmucosal fentanyl citrate.

James B. Streisand, John R. Varvel, +5 authors Theodore H. Stanley
Anesthesiology
1991

Oral transmucosal fentanyl citrate (OTFC) is a novel, noninvasive dosage form of fentanyl used to provide children and adults with sedation, anxiolysis, and analgesia. In order to determine the… (More)

Population pharmacokinetics of alfentanil: the average dose-plasma concentration relationship and interindividual variability in patients

Pierre O. Maitre, S. Vožeh, Joseph Heykants, Debra Thomson, Donald R. Stanski
Anesthesiology
1987

The population pharmacokinetic parameters describing the plasma concentration versus time profile of alfentanil in patients undergoing general anesthesia were determined from 614 plasma concentration… (More)

EEG quantitation of narcotic effect: the comparative pharmacodynamics of fentanyl and alfentanil.

James C. Scott, Katherine V. Ponganis, Donald R. Stanski
Anesthesiology
1985

Fentanyl and alfentanil produce very similar electroencephalographic (EEG) changes in humans. With increasing serum concentrations of either narcotic, progressive slowing in frequency occurs. This… (More)

Characterization and validation of a pharmacokinetic model for controlled-release oxycodone.

Jaap W. Mandema, R F Kaiko, B Oshlack, Robert F Reder, Donald R. Stanski
British journal of clinical pharmacology
1996

1. Oxycodone is a strong opioid agonist that is currently available in immediate-release (IR) formulations for the treatment of moderate to severe pain. Recently, controlled-release (CR) oxycodone… (More)

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