Learn More
pharmacological agents that are able to influence the pancreatic B-cell? Work in our laboratory has been generously funded by project/equipment grants to M. In trod uction In a number of cells, including the pancreatic B-cell, cytoplasmic free Ca2+ ([Ca2+Ii) has a fundamental role in signal transduction. Over the years we have +-induced CaZ + release. 'To(More)
BACKGROUND Many growth factors, such as bone morphogenetic protein (BMP)-2, have been shown to interact with polymers of sulfated disacharrides known as heparan sulfate (HS) glycosaminoglycans (GAGs), which are found on matrix and cell-surface proteoglycans throughout the body. HS GAGs, and some more highly sulfated forms of chondroitin sulfate (CS),(More)
  • 1