Donald P McDonnell

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Human progesterone receptor A form is a cell- and promoter-specific repressor of human progesterone receptor B function.

Elisabetta Vegeto, Manou Shahbaz, Denggui Wen, Mark Evan Goldman, Bert W O'malley, Donald P McDonnell
Molecular endocrinology
1993

Two distinct isoforms of the human progesterone receptor (hPR-A and hPR-B) have been identified previously. They differ only in that hPR-B contains an additional 164 amino acids at the amino… (More)

The estrogen receptor beta-isoform (ERbeta) of the human estrogen receptor modulates ERalpha transcriptional activity and is a key regulator of the cellular response to estrogens and antiestrogens.

Julie M. Hall, Donald P McDonnell
Endocrinology
1999

The human estrogen receptor alpha (ERalpha) and the recently identified ERbeta share a high degree of amino acid homology; however, there are significant differences in regions of these receptors… (More)

Evaluation of chemicals with endocrine modulating activity in a yeast-based steroid hormone receptor gene transcription assay.

Kevin W Gaido, Linda S Leonard, +4 authors Donald P McDonnell
Toxicology and applied pharmacology
1997

There is a concern that chemicals in our environment are affecting human health by disrupting normal endocrine function. Much of the concern has focused on chemicals that can interact directly with… (More)

27-Hydroxycholesterol links hypercholesterolemia and breast cancer pathophysiology.

Erik R Nelson, Suzanne E. Wardell, +10 authors Donald P McDonnell
Science
2013

Hypercholesterolemia is a risk factor for estrogen receptor (ER)-positive breast cancers and is associated with a decreased response of tumors to endocrine therapies. Here, we show that… (More)

Analysis of estrogen receptor function in vitro reveals three distinct classes of antiestrogens.

Donald P McDonnell, David L. Clemm, Thomas Hermann, Mark Evan Goldman, John Wesley Pike
Molecular endocrinology
1995

We have developed a series of in vitro models with which to evaluate the biological activity of estrogen receptor (ER) agonists and antagonists. Using a protease digestion assay we show that the… (More)

Human estrogen receptor transactivational capacity is determined by both cellular and promoter context and mediated by two functionally distinct intramolecular regions.

Maty Tzukerman, Abby Esty, +5 authors Donald P McDonnell
Molecular endocrinology
1994

We have used a series of human estrogen receptor (ER) mutants to evaluate the cell- and promoter-specific transcriptional activities of the TAF1 and TAF2 transactivation regions within the human ER.… (More)

Cloning and expression of full-length cDNA encoding human vitamin D receptor.

Albert Rufus Baker, Donald P McDonnell, +6 authors Bert W O'malley
Proceedings of the National Academy of Sciences…
1988

Complementary DNA clones encoding the human vitamin D receptor have been isolated from human intestine and T47D cell cDNA libraries. The nucleotide sequence of the 4605-base pair (bp) cDNA includes a… (More)

The opposing transcriptional activities of the two isoforms of the human progesterone receptor are due to differential cofactor binding.

P. Giangrande, Erin A. Kimbrel, Dean P. Edwards, Donald P McDonnell
Molecular and cellular biology
2000

The human progesterone receptor (PR) exists as two functionally distinct isoforms, hPRA and hPRB. hPRB functions as a transcriptional activator in most cell and promoter contexts, while hPRA is… (More)

Variant human breast tumor estrogen receptor with constitutive transcriptional activity.

Suzanne A W Fuqua, Scott D. Fitzgerald, +5 authors William L. McGuire
Cancer research
1991

Since progesterone receptor (PgR) is normally induced by estrogen, breast cancer lacking estrogen receptor (ER) would also be expected to lack PgR. However, a small percentage of breast cancers are… (More)

Inhibition of aldehyde dehydrogenase and retinoid signaling induces the expansion of human hematopoietic stem cells.

John P. Chute, Garrett G. Muramoto, +4 authors Donald P McDonnell
Proceedings of the National Academy of Sciences…
2006

Aldehyde dehydrogenase (ALDH) is an enzyme that is expressed in the liver and is required for the conversion of retinol (vitamin A) to retinoic acids. ALDH is also highly enriched in hematopoietic… (More)

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