Donald O'Leary

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Injured dorsal root axons fail to regenerate into the adult spinal cord, leading to permanent sensory loss. We investigated the ability of intrathecal neurotrophin-3 (NT3) to promote axonal regeneration across the dorsal root entry zone (DREZ) and functional recovery in adult rats. Quantitative electron microscopy showed robust penetration of CNS tissue by(More)
NMR studies of living cells and of perfused organs almost invariably require a major effort in the design of either the probe or the support system. For enriched 13C studies of metabolism, it is sometimes possible to use a simpler approach, one amenable to use in narrow-bore high-resolution NMR spectrometers. Since some of the metabolic changes are(More)
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