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OBJECTIVE Both amyloid-β (Aβ) deposition and brain atrophy are associated with Alzheimer's disease (AD) and the disease process likely begins many years before symptoms appear. We sought to determine whether clinically normal (CN) older individuals with Aβ deposition revealed by positron emission tomography (PET) imaging using Pittsburgh Compound B (PiB)(More)
The increasing number and density of the human population, the emergence of lethal influenza strains, and the potential use of designer influenza virus as a bioweapon, collectively highlight a critical need for more rapid production of influenza vaccines and less invasive means of delivery. We have developed a nonreplicative adenovirus-vectored influenza(More)
BACKGROUND Emergency departments (EDs) have strong potential to initiate tobacco interventions with economically disadvantaged populations. PURPOSE We piloted three ED-initiated tobacco interventions and derived parameter estimates for future trials. METHODS The study enrolled adult patients being treated in an urban ED who were daily smokers. Exclusion(More)
BACKGROUND There are approximately 400,000 National Collegiate Athletic Association (NCAA) student athletes and 5-7 million high school student athletes competing each year. According to the US Department of Health and Human Services, the depression prevalence rate for young adults, which ranges from 10% to 85% across studies, is higher than that of other(More)
Mild cognitive impairment (MCI), a perceivable decrease in thought processes, primarily memory, occurs in individuals who are otherwise able to function in everyday activities. These patients have difficulty remembering the names of people, performing calculations, navigating in a mall parking lot, and keeping track of common objects. Various levels of(More)
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