Donald L. Price

Sort by:

ALS-Linked SOD1 Mutant G85R Mediates Damage to Astrocytes and Promotes Rapidly Progressive Disease with SOD1-Containing Inclusions

Lucie I. Bruijn, Mark W. Becher, +8 authors Don W Cleveland
Neuron
1997

High levels of familial Amyotrophic Lateral Sclerosis (ALS)-linked SOD1 mutants G93A and G37R were previously shown to mediate disease in mice through an acquired toxic property. We report here that… (More)

Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin.

Gabriele Schilling, Mark W. Becher, +11 authors David R Borchelt
Human molecular genetics
1999

Huntington's disease (HD) is an inherited, neurodegenerative disorder caused by the expansion of a glutamine repeat in the N-terminus of the huntingtin protein. To gain insight into the pathogenesis… (More)

An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria

Philip Chuen Yung Wong, Carlos A Pardo, +6 authors Donald L. Price
Neuron
1995

Mutations in Cu/Zn superoxide dismutase (SOD1) cause a subset of cases of familial amyotrophic lateral sclerosis. Four lines of mice accumulating one of these mutant proteins (G37R) develop severe,… (More)

Familial Alzheimer's Disease–Linked Presenilin 1 Variants Elevate Aβ1–42/1–40 Ratio In Vitro and In Vivo

David R Borchelt, Gopal Thinakaran, +17 authors Sangram S. Sisodia
Neuron
1996

Mutations in the presenilin 1 (PS1) and presenilin 2 genes cosegregate with the majority of early-onset familial Alzheimer's disease (FAD) pedigrees. We now document that the Abeta1-42(43)/Abeta1-40… (More)

Accelerated Amyloid Deposition in the Brains of Transgenic Mice Coexpressing Mutant Presenilin 1 and Amyloid Precursor Proteins

David R Borchelt, Tamara Ratovitski, +6 authors Sangram S. Sisodia
Neuron
1997

Missense mutations in two related genes, termed presenilin 1 (PS1) and presenilin 2 (PS2), cause dementia in a subset of early-onset familial Alzheimer's disease (FAD) pedigrees. In a variety of… (More)

Endoproteolysis of Presenilin 1 and Accumulation of Processed Derivatives In Vivo

Gopal Thinakaran, David R Borchelt, +14 authors Sangram S. Sisodia
Neuron
1996

The majority of early-onset cases of familial Alzheimer's disease (FAD) are linked to mutations in two related genes, PS1 and PS2, located on chromosome 14 and 1, respectively. Using two highly… (More)

Identification and localization of muscarinic acetylcholine receptor proteins in brain with subtype-specific antibodies.

Allan I. Levey, Cheryl A. Kitt, William F. Simonds, Donald L. Price, Mark R. Brann
The Journal of neuroscience : the official…
1991

mRNAs encoding five genetically distinct muscarinic ACh receptors are present in the CNS. Because of their pharmacological similarities, it has not been possible to detect the individual encoded… (More)

BACE1, a major determinant of selective vulnerability of the brain to amyloid-beta amyloidogenesis, is essential for cognitive, emotional, and synaptic functions.

Fiona M Laird, Huaibin Cai, +11 authors Philip Chuen Yung Wong
The Journal of neuroscience : the official…
2005

A transmembrane aspartyl protease termed beta-site APP cleavage enzyme 1 (BACE1) that cleaves the amyloid-beta precursor protein (APP), which is abundant in neurons, is required for the generation of… (More)

Alzheimer's disease and senile dementia: loss of neurons in the basal forebrain.

Peter J. Whitehouse, Donald L. Price, Robert G. Struble, Arthur W Clark, Joseph T Coyle, M R Delon
Science
1982

Recent evidence indicates that the nucleus basalis of Meynert, a distinct population of basal forebrain neurons, is a major source of cholinergic innervation of the cerebral cortex. Postmortem… (More)

Localization of D1 and D2 dopamine receptors in brain with subtype-specific antibodies.

Allan I. Levey, Steven M. Hersch, +7 authors Brian J. Ciliax
Proceedings of the National Academy of Sciences…
1993

Five or more dopamine receptor genes are expressed in brain. However, the pharmacological similarities of the encoded D1-D5 receptors have hindered studies of the localization and functions of the… (More)

Filter Results:

Publication Year

Publication Type

Co-author

Journals and Conferences