Donald L. Bitzer

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In prokaryotes, Shine-Dalgarno (SD) sequences, nucleotides upstream from start codons on messenger RNAs (mRNAs) that are complementary to ribosomal RNA (rRNA), facilitate the initiation of protein synthesis. The location of SD sequences relative to start codons and the stability of the hybridization between the mRNA and the rRNA correlate with the rate of(More)
Our research explores the feasibility of using communication theory, error control (EC) coding theory specifically, for quantitatively modeling the protein translation initiation mechanism. The messenger RNA (mRNA) of Escherichia coli K-12 is modeled as a noisy (errored), encoded signal and the ribosome as a minimum Hamming distance decoder, where the 16S(More)
A fundamental challenge for engineering communication systems is the problem of transmitting information from the source to the receiver over a noisy channel. This same problem exists in a biological system. How can information required for the proper functioning of a cell, an organism, or a species be transmitted in an error introducing environment? Source(More)
incorporate some form of knowledge testing. Unfortunately, facilities for tracking and evaluation of user knowledge, and for interactive feedback, are precisely what is lacking in the Web interfaces that are readily available today (e.g., browsers). This has motivated a number of researchers to discuss and develop systems that support development of(More)
The option of obtaining education over networks is quickly becoming a reality for all those that have access to Internet and World-Wide Web (WWW). However, at present network-based education (NBE) over WWW, and over Internet in general, faces a number of pitfalls. The problems range from inadequate enduser quality of service (QoS), to inadequate materials,(More)
The q-matrix method, a new method for data mining and knowledge discovery, is compared with factor analysis and cluster analysis in analyzing fourteen experimental data sets. This method creates a matrix-based model that extracts latent relationships among observed binary variables. Results show that the q-matrix method offers several advantages over factor(More)
A decoding algorithm is tested that mechanistically models the progressive alignments that arise as the mRNA moves past the rRNA tail during translation elongation. Each of these alignments provides an opportunity for hybridization between the single-stranded, 3'-terminal nucleotides of the 16S rRNA and the spatially accessible window of mRNA sequence, from(More)