Donald L. Bitzer

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In prokaryotes, Shine-Dalgarno (SD) sequences, nucleotides upstream from start codons on messenger RNAs (mRNAs) that are complementary to ribosomal RNA (rRNA), facilitate the initiation of protein synthesis. The location of SD sequences relative to start codons and the stability of the hybridization between the mRNA and the rRNA correlate with the rate of(More)
The option of obtaining education over networks is quickly becoming a reality for all those that have access to Internet and WorldWide Web (WWW). However, at present network-based education (NBE) over WWW, and over Internet in general, faces a number of pitfalls. The problems range from inadequate end-user quality of service (QoS), to inadequate materials,(More)
Lip synchronization is the determination of the motion of the mouth and tongue during speech. It can be deduced from the speech signal without phonemic analysis, and irrespective of the content of the speech. Our method is based on the observation that the position of the mouth over a short interval of time can be correlated with the basic shape of the(More)
The q-matrix method, a new method for data mining and knowledge discovery, is compared with factor analysis and cluster analysis in analyzing fourteen experimental data sets. This method creates a matrix-based model that extracts latent relationships among observed binary variables. Results show that the q-matrix method offers several advantages over factor(More)
Our research explores the feasibility of using communication theory, error control (EC) coding theory specifically, for quantitatively modeling the protein translation initiation mechanism. The messenger RNA (mRNA) of Escherichia coli K-12 is modeled as a noisy (errored), encoded signal and the ribosome as a minimum Hamming distance decoder, where the 16S(More)
This work gives a brief overview of information theory based approaches to genetic sequence and system analysis. The state of research with regard to error-correction coding theory methods for evaluating the genetic translation initiation system is explored. We present research results of interest in the area of error-control coding methods for modeling the(More)
By analyzing the absolute value of the Fourier transform of a speaker's voice signal we can predict the position of the mouth for English vowel sounds. This is without the use of text, speech recognition or mechanical or other sensing devices attached to the speaker's mouth. This capability can reduce the time required for mouth animation considerably. We(More)
A decoding algorithm is tested that mechanistically models the progressive alignments that arise as the mRNA moves past the rRNA tail during translation elongation. Each of these alignments provides an opportunity for hybridization between the single-stranded, 3'-terminal nucleotides of the 16S rRNA and the spatially accessible window of mRNA sequence, from(More)