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  • Neil P. Desai, Vuong N Trieu, +12 authors Patrick Soon-Shiong
  • Medicine
  • Clinical cancer research : an official journal of…
  • 2006 (First Published: 15 February 2006)
  • ABI-007, an albumin-bound, 130-nm particle form of paclitaxel, was developed to avoid Cremophor/ethanol-associated toxicities in Cremophor-based paclitaxel (Taxol) and to exploit albuminContinue Reading
  • Alvin M. Malkinson, Doreen Siegel, +7 authors Steadman D. Harrison
  • Biology, Medicine
  • Cancer research
  • 1992 (First Published: 1 September 1992)
  • The enzyme DT-diaphorase (DTD; NAD(P)H:quinone oxidoreductase, EC 1.6.99.2), is an obligate two electron reductase which catalyzes reduction of a broad range of substrates, including quinones. WeContinue Reading
  • Sylvester Klutchko, James Marino Hamby, +22 authors Annette Marian Doherty
  • Chemistry, Medicine
  • Journal of medicinal chemistry
  • 1998 (First Published: 1 August 1998)
  • While engaged in therapeutic intervention against a number of proliferative diseases, we have discovered the 2-aminopyrido[2, 3-d]pyrimidin-7(8H)-ones as a novel class of potent, broadly activeContinue Reading
  • Patrick W. Vincent, Alex J. Bridges, +8 authors William Leland Elliott
  • Medicine
  • Cancer Chemotherapy and Pharmacology
  • 2000 (First Published: 1 February 2000)
  • Purpose: The involvement of the EGF receptor (EGFr) family of receptors in cancers suggests that a selective inhibitor of the tyrosine kinase activity of the EGFr family could have a therapeuticContinue Reading