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Metabonomics and its many pseudonyms (metabolomics, metabolic profiling, etc.) have exploded onto the scientific scene in the past 2 to 3 years. Nowhere has the impact been more profound than within the toxicology community. Within this community there exists a great deal of uncertainty about whether metabonomics is something to count on or just the most(More)
Gait patterns for the non-amputated leg of eight elderly men with trans-tibial amputations were assessed using kinematic and kinetic measures. Kinematically, the subject's walking speed was faster than expected but less than normative non-amputee data. The stride length was also less than non-amputee norms. Net joint moment and power analyses showed various(More)
Experiments were conducted on normal level gait to determine the synergistic patterns present in the forces causing joint moments and those associated with the generation, absorption and transfer of mechanical energy. The following generalizations can be made about the patterns: (i) During swing phase three forces (gravitational, muscle and knee joint(More)
The purpose of this study was to determine whether there was a difference in the electromyographic (EMG) patterns of the quadriceps muscles in women runners diagnosed with patellofemoral pain syndrome (PFPS) compared to the quadriceps activity of women runners free of knee pain and with normal lower extremity alignment. Linear envelope EMGs from vastus(More)
The purpose of this study was to determine the contributions made by the leg muscle groups to the external mechanical work done in standing broad and vertical jumping. Six subjects were filmed jumping from a force platform. Linked-segment analysis and inverse dynamics methods were used to compute the muscle moments of force and power and work output created(More)
Genetic drift in animal populations has been a recognized concern for many years. Less understood is the potential for phenotypic "drift" or variation that is not related to any genetic change. Recently, stock Sprague-Dawley (Crl:CD(SD)) rats obtained from the Charles River Raleigh facility demonstrated a distinct endogenous urinary metabonomic profile that(More)
Nonalcoholic fatty liver disease (NAFLD) is a globally widespread disease of increasing clinical significance. The pathological progression of the disease from simple steatosis to nonalcoholic steatohepatitis (NASH) has been well defined, however, the contribution of altered branched chain amino acid metabolomic profiles to the progression of NAFLD is not(More)
The relative efficacy of rotations of soybean with sorghum and tropical corn for nematode management was studied for 2 years in a field infested with root-knot (Meloidogyne arenaria) and soybean cyst (Heterodera glycines, race 14) nematodes. Corn, sorghum, and soybean cv. Kirby were planted in 1989, and in 1990 the same areas were planted with seven soybean(More)
The pathology induced by trimethyltin in the hippocampus was investigated using a detailed morphometric model. Male Long-Evans rats were dosed with 3 mg/kg trimethyltin chloride (TMT) for three consecutive days and sacrificed at subsequent interim period. Total brain volume was not significantly affected; hippocampus volume decreased within 4 days after(More)
Hydrous carbonate sequestration of carbon dioxide using steelmaking slag was studied using a METSIM process model to analyze experimental data and estimate the reactor operating results. Several scenarios of a two-stage system with water/slag contact in reactor 1 and leachate/carbon dioxide contact in reactor 2 were investigated. These scenarios included(More)