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- Donald E Kohan, Noreen F Rossi, Edward W. Inscho, David M Pollock
- Physiological reviews
- 2011
Endothelin (ET) peptides and their receptors are intimately involved in the physiological control of systemic blood pressure and body Na homeostasis, exerting these effects through alterations in a… (More)
- You-fei Guan, Chuanming Hao, +7 authors Matthew D. Breyer
- Nature Medicine
- 2005
Thiazolidinediones (TZDs) are widely used to treat type 2 diabetes mellitus; however, their use is complicated by systemic fluid retention. Along the nephron, the pharmacological target of TZDs,… (More)
- Donald E Kohan, Paola Fioretto, Weihua Tang, J. F. Van Der List
- Kidney international
- 2014
In patients with diabetes, glycemic improvement by sodium-glucose cotransporter-2 inhibition depends on the kidney's ability to filter glucose. Dapagliflozin, a sodium-glucose cotransporter-2… (More)
- Dowhan Ahn, Yuqiang Ge, +7 authors Donald E Kohan
- The Journal of clinical investigation
- 2004
In vitro studies suggest that collecting duct-derived (CD-derived) endothelin-1 (ET-1) can regulate renal Na reabsorption; however, the physiologic role of CD-derived ET-1 is unknown. Consequently,… (More)
- Donald E Kohan
- American journal of kidney diseases : the…
- 1997
Endothelin-1 (ET-1) is a 21-amino acid peptide that potently modulates renal function. ET-1 is produced by, and binds to, most renal cell types. ET-1 exerts a wide range of biologic effects in the… (More)
- David Pearce, Rama Soundararajan, Christiane Trimpert, Ossama B Kashlan, Peter M T Deen, Donald E Kohan
- Clinical journal of the American Society of…
- 2015
The principal cell of the kidney collecting duct is one of the most highly regulated epithelial cell types in vertebrates. The effects of hormonal, autocrine, and paracrine factors to regulate… (More)
- Donald E Kohan, Eugenia Padilla, Alisa K Hughes
- The American journal of physiology
- 1993
Endothelin (ET) potently inhibits arginine vasopressin (AVP)-induced adenosine 3',5'-cyclic monophosphate (cAMP) accumulation and Na-K-adenosinetriphosphatase (Na-K-ATPase) activity in the inner… (More)
- Hui Zhang, Aihua Zhang, Donald E Kohan, R Darrell Nelson, Frank J. Gonzalez, Tianxin Yang
- Proceedings of the National Academy of Sciences…
- 2005
The peroxisome proliferator-activated receptor subtype gamma (PPARgamma) ligands, namely the synthetic insulin-sensitizing thiazolidinedione (TZD) compounds, have demonstrated great potential in the… (More)
- Kevin A. Strait, Peter K. Stricklett, Mark Chapman, Donald E Kohan
- American journal of physiology. Renal physiology
- 2010
Little is known about collecting duct adenylyl cyclase (AC) isoforms or regulation in the mouse. We performed RT-PCR for AC isoforms 1-9 in microdissected cortical (CCD) and outer medullary (OMCD)… (More)
- Yuqiang Ge, A. G. Bagnall, +4 authors Donald E Kohan
- American journal of physiology. Renal physiology
- 2006
Collecting duct (CD)-derived endothelin-1 (ET-1) inhibits renal Na reabsorption and its deficiency increases blood pressure (BP). The role of CD endothelin B (ETB) receptors in mediating these… (More)