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BACKGROUND Previous meta-analyses reported by Gould et al found significant decreases of 15% in the risk for coronary heart disease (CHD)-related mortality and 11 % in risk for all-cause mortality per decrease of 10% in total cholesterol (TC) level. OBJECTIVE To evaluate the effects of reducing cholesterol on clinical events after including data from(More)
BACKGROUND There is substantial evidence that treatment with lipid-lowering agents can decrease cardiovascular morbidity and total mortality in patients with elevated serum lipid values and/or prior ischaemic heart disease. However, only a minority of these high-risk patients are believed to receive treatment, and among those who do receive pharmaceutical(More)
BACKGROUND Although the economic burden of pediatric asthma is a significant public health issue, the loss of workdays by caregivers because of their children's asthma remains scarcely investigated. OBJECTIVES To evaluate asthma-related loss of workdays incurred by caregivers of asthmatic children and its association with the level of asthma control. (More)
BACKGROUND Asthma and allergic rhinitis (AR) frequently coexist, but have usually been studied separately in health economic analyses. OBJECTIVE To determine the incremental effect of documented AR on health care resource use in adults with asthma. METHODS A retrospective cohort study using data from a UK general practice database for the period(More)
BACKGROUND To evaluate the association between patient-reported hypoglycemic symptoms with ratings of their health-related quality of life state and patient-reported adverse events in patients with type 2 diabetes mellitus (T2DM). METHODS This observational, multicenter, cross sectional study was based on a sample of patients with T2DM from seven European(More)
BACKGROUND Inadequately controlled allergic rhinitis (AR) in asthmatic patients can contribute towards increased asthma exacerbations and poorer symptom control, which may increase medical resource use. We assessed asthma-related medical resource use and attacks in asthmatic patients who did and did not have concomitant AR and were adding montelukast or(More)
AIMS We examined the relationship of hypoglycemic symptoms with health-related quality of life and worry about hypoglycemia among type 2 diabetic patients using oral antihyperglycemic agents (AHA) in the Asia-Pacific region. METHODS A total of 2257 type 2 diabetic patients with at least 6 months of oral AHA were enrolled in China, Korea, Malaysia,(More)
OBJECTIVE The objective of this study was to compare the inpatient resource use and cost of care for patients hospitalised with community-acquired pneumonia (CAP) who were treated with preferred antibacterial therapy according to the 1998 Infectious Diseases Society of America (IDSA) guidelines with those who were not treated with preferred therapy. (More)
OBJECTIVE We sought to develop stroke risk equations for Chinese patients with type 2 diabetes in Hong Kong. RESEARCH DESIGN AND METHODS A total of 7,209 Hong Kong Chinese type 2 diabetic patients without a history of stroke at baseline were analyzed. The data were randomly and evenly divided into the training subsample and the test subsample. In the(More)
OBJECTIVE To determine the incremental effect of allergic rhinitis on health care resource use in children with asthma. DESIGN Population-based historical cohort study. SETTING Data in a general practice database in the United Kingdom during 1998 to 2001. PATIENTS Children 6 to 15 years old with asthma and with >or=1 asthma-related visits to a general(More)