Donald Blake Fuller

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BACKGROUND We tested our ability to approximate the dose (38 Gy), fractionation (four fractions), and distribution of high-dose-rate (HDR) brachytherapy for prostate cancer with CyberKnife (CK) stereotactic body radiotherapy (SBRT) plans. We also report early clinical observations of CK SBRT treatment. METHODS AND MATERIALS Ten patients were treated with(More)
PURPOSE The purpose of this study was to evaluate the influence of potential contributing factors to the incidence of seed migration and quality of prostate brachytherapy dosimetry. METHODS AND MATERIALS Sixty patients were evaluated with day one and 3-12 month plain films of the pelvis and chest, and day 1 CT-based dosimetry analysis. The incidence and(More)
PURPOSE The effectiveness of stereotactic body radiotherapy (SBRT) for localized prostate cancer is tested. METHODS AND MATERIALS A total of 1100 patients with clinically localized prostate cancer were enrolled in separate prospective phase 2 clinical trials of SBRT from 8 institutions during 2003-11 and pooled for analysis. SBRT using the CyberKnife(More)
PURPOSE To evaluate the early and late health-related quality of life (QOL) outcomes among prostate cancer patients following stereotactic body radiation therapy (SBRT). METHODS AND MATERIALS Patient self-reported QOL was prospectively measured among 864 patients from phase 2 clinical trials of SBRT for localized prostate cancer. Data from the Expanded(More)
Twenty-four patients with superior sulcus tumors were seen between 1955 and 1989. Fifteen of these patients received combined-modality therapy. In 2 patients, this consisted of primary operation followed by postoperative radiotherapy, and, in 13, high-dose conventionally fractionated preoperative radiotherapy (5,500 to 6,475 cGy) followed by en bloc(More)
OBJECTIVE The purpose of this study was to evaluate the utility of dynamic gadolinium-enhanced perfusion MRI for monitoring the response to robotic stereotactic body radiation therapy for prostate cancer. MATERIALS AND METHODS Eighty-seven patients with prostate cancer underwent dynamic gadolinium-enhanced MRI before robotic stereotactic body radiation(More)
45 Background: We designed a CyberKnife (CK) prostate Stereotactic Body Radiotherapy (SBRT) method to recapitulate HDR fractionation and target volume coverage ("Virtual HDR"). We report 4 year efficacy, toxicity and quality of life (QoL) outcomes. METHODS Eligible patients had low- (Gleason < 6, PSA < 10 ng/mL, < T2bN0) or intermediate-risk (Gleason < 6(More)
PURPOSE The authors describe a prostate brachytherapy technique with dynamic dosimetry feedback, using coregistered CT and ultrasound (US) images, to map initial dosimetry deficiencies and guide remedial source placement. METHODS AND MATERIALS Fifty-four consecutive patients treated with this method were analyzed for coregistration accuracy and dosimetry(More)
PURPOSE Prostate stereotactic body radiotherapy (SBRT) may substantially recapitulate the dose distribution of high-dose-rate (HDR) brachytherapy, representing an externally delivered "Virtual HDR" treatment method. Herein, we present 5-year outcomes from a cohort of consecutively treated virtual HDR SBRT prostate cancer patients. METHODS Seventy-nine(More)