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Behavioral studies have suggested that exaggerated reactivity to food cues, especially those associated with high-calorie foods, may be a factor underlying obesity. This increased motivational potency of foods in obese individuals appears to be mediated in part by a hyperactive reward system. We used a Philips 3T magnet and fMRI to investigate activation of(More)
PURPOSE To determine thresholds of quality for a T2*-weighted perfusion magnetic resonance imaging (MRI) study and evaluate the effects of an angiogenesis inhibitor on relative blood flow and volume changes in brain tumor patients in a multi-institution setting. MATERIALS AND METHODS A total of 36 volunteers from four participating institutions with(More)
Functional magnetic resonance imaging (fMRI) has developed rapidly into a major non-invasive tool for studying the human brain. However, due to a variety of technical difficulties, it has yet to be widely adopted for use in alert, trained non-human primates. Our laboratory has been developing techniques for such fMRI studies. As background, we first(More)
A variety of applications and research directions in magnetic resonance imaging which require fast scan times have recently become popular. In order to satisfy many of the requirements of these applications, snapshot imaging methods, which acquire an entire image in one excitation, are often used. These snapshot techniques are relatively insensitive to(More)
In this work a new single-shot MRI method, single-shot parameter assessment by retrieval from signal encoding (SS-PARSE), is introduced. This method abandons a fundamental simplifying assumption that is used in conventional MRI methods. Established MRI methods implicitly assume that the local intrinsic signal does not change its amplitude or phase during(More)
Models of addiction include abnormalities in parts of the brain involving executive function/inhibitory control. Although previous studies have reported evidence of structural abnormalities in cocaine-dependent individuals, none have specifically targeted the homeless. The present preliminary study investigated brain structure in such an understudied group,(More)
Spatial independent component analysis (ICA) was used to study the temporal stationarity and spatial consistency of structured functional MRI (fMRI) noise. Spatial correlations have been used in the past to generate filters for the removal of structured noise for each time-course in an fMRI dataset. It would be beneficial to produce a multivariate filter(More)
Single shot parameter assessment by retrieval from signal encoding (SS-PARSE) is a recently introduced method to obtain quantitative parameter maps from a single-shot (typically 65 ms) magnetic resonance imaging (MRI) signal. Because it explicitly models local magnetization decay and phase evolution occurring during the signal 1) it can provide quantitative(More)
Spin-echo signals allow separate measurements of irreversible and reversible relaxation rates in MRI. A spin-echo version of single-shot parameter assessment by retrieval from signal encoding (SE-SS-PARSE) method has been developed to quantitatively and accurately map transverse magnetization magnitude, frequency, irreversible and reversible relaxation(More)
As a variant of Single-Shot Parameter Assessment by Retrieval from Signal Encoding, Velocity Single-Shot Parameter Assessment by Retrieval from Signal Encoding, a single-shot imaging method, has been developed to realize fast and straightforward flow quantification by solving inverse problems. A robust signal model, including its local magnetization and its(More)