Donal O'Brien

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BACKGROUND The neurobiological basis of stress and anxiety in primates remains poorly understood. In this study, we examined the neural response to a naturalistic social stressor: maternal separation. We used rhesus monkeys as an animal model because of their close phylogenetic affinity with humans. METHODS Six juvenile rhesus monkeys received(More)
Agile development methods are growing in popularity with a recent survey reporting that more than 80% of organizations now following an agile approach. Agile methods were seen initially as best suited to small, co-located teams developing non-critical systems. The first two constraining characteristics (small and co-located teams) have been addressed as(More)
OBJECTIVES The aims of this study are to determine the incidence and aetiology of major obstetric haemorrhage (MOH) in our population, to examine the success rates of medical and surgical interventions and to identify risk factors for peripartum hysterectomy and end organ dysfunction (EOD). STUDY DESIGN This prospective study from 2004 to 2007 was carried(More)
This investigation examined the formulation of diagnostic hypotheses by general internists and family physicians in response to three patient cases (dyspnea, abdominal pain and syncope). The investigation was conducted in the United States. Physician responses to sequentially presented written clinical information were audiotaped. Each transcribed protocol(More)
Clinical reasoning involves an element of uncertainty. Teaching clinical reasoning involves understanding how students view uncertainty as well as how medical problems are solved. This study uses Perry's model of intellectual development to explore changes in how medical students, residents, and instructors think about the nature of knowledge. A total of 31(More)
The importance of a comprehensive documentation system for assisting residents in securing hospital privileges has been widely asserted. Other applications of a documentation system such as encouraging research, providing individual resident evaluations, and providing program evaluation are also worthy reasons for developing a system. This paper describes a(More)
The effects of four commonly prescribed diuretics on serum potassium were assessed. One hundred sixteen elderly clinic patients, independently living, (mean age 74.3 years, range 60 to 99 years) were taking hydrochlorothiazide (HCTZ) (n = 40; mean daily dose, 53.9 mg), a combination of hydrochlorothiazide-triamterene (HCTZ-TMTR) (n = 38; mean daily dose,(More)
Utilization of a selected set of laboratory tests in the ambulatory setting was determined for four classes of family practice residents over their entire three year training program. A total of nineteen residents were included in the study. Residents' test utilization in their third year of training was significantly lower than in their Post Graduate Year(More)