Don Williamson

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The Look AHEAD (Action for Health in Diabetes) study is a multicenter, randomized controlled trial designed to determine whether intentional weight loss reduces cardiovascular morbidity and mortality in overweight individuals with type 2 diabetes. The study began in 2001 and is scheduled to conclude in 2012. A total of 5145 participants have been randomly(More)
In the United States, many vaccine-preventable disease rates are at an all-time low. Low disease rates have been achieved through high rates of immunization coverage. Vaccination requirements for school and child care attendance have been recommended by the independent Task Force on Community Preventive Services based on systematic review of immunization(More)
OBJECTIVE To study the association of depressive symptoms or antidepressant medicine (ADM) use with subsequent cardiovascular disease (CVD) risk factor status in the Look AHEAD (Action for Health in Diabetes) trial of weight loss in type 2 diabetes. RESEARCH DESIGN AND METHODS Participants (n = 5,145; age [mean ± SD] 58.7 ± 6.8 years; BMI 35.8 ± 5.8(More)
PURPOSE To demonstrate how principal components analysis can be used to describe patterns of weight changes in response to an intensive lifestyle intervention. METHODS Principal components analysis was applied to monthly percent weight changes measured on 2,485 individuals enrolled in the lifestyle arm of the Action for Health in Diabetes (Look AHEAD)(More)
BACKGROUND Although the vaccine research and development network in the United States remains vibrant, its continued success requires maintaining harmonious interaction among its many components. Changing one component is likely to affect the system overall. An examination of case studies of the development of selected vaccines would allow an examination of(More)
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