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Primary cilia are cellular appendages important for signal transduction and sensing the environment. Bardet-Biedl syndrome proteins form a complex that is important for several cytoskeleton-related processes such as ciliogenesis, cell migration and division. However, the mechanism by which BBS proteins may regulate the cytoskeleton remain unclear. We(More)
There has been considerable recent interest in the roles of vesicle transport proteins in ciliary biology and regulation of signal transduction. We have previously discovered RAB23 mutations in Carpenter syndrome, in which patients present with craniofacial and cardiac malforma-tions, postnatal obesity and tumour formation, and Rab23 regulates trafficking(More)
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