Don Guthrie

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It has been suggested that patients with schizophrenia have corticostriatal circuit dysfunction (Carlsson & Carlsson, 1990). Skill learning is thought to rely on corticostriatal circuitry and different types of skill learning may be related to separable corticostriatal loops (Grafton, Hazeltine, & Ivry, 1995; Poldrack, Prabhakaran, Seger, & Gabrieli, 1999).(More)
OBJECTIVE This study examined women's cardiovascular and neuroendocrine responsiveness to work. METHODS Ambulatory blood pressure (BP) and heart rate (HR) were recorded over 24-hour periods on 2 work and 2 off days during the luteal and follicular phases of the menstrual cycle in 138 registered nurses, aged 25 to 50 years. Urinary catecholamines and(More)
Recordings from the intrinsic tectal cells of the perch have allowed a classification of visual units on the basis of receptive field type. Comparisons with retinal and tectal cells in carp, goldfish, pike, trout and in the Anura were made. Most striking are cells with vertical bar-shaped features forming part of the R.F. The relation between the receptive(More)
Intrinsic cells from the optic tectum of the goldfish were recorded intracellularly while undergoing photic stimulation, injected iontophoretically with horseradish peroxidase (HRP), and subsequently recovered in sectioned material. Unequivocal identifications were possible for 72 cells. The majority of these belonged to type I or type XIV, but types II,(More)
The results of localized electrical stimulation of the teleostean tectum indicate the presence within each tectal lobe of separate motor areas mediating ipsilateral turning, contralateral turning, and rolling movements. Stimulation of caudal regions produced larger turning circles than stimulation of rostral sites. Both these sets of observations conflict(More)
This study explored the relationship between cognitive function and blood pressure (BP) in 84 women and 64 men, aged 55-79. Assessments were made of casual BP, 24-hour ambulatory BP, and cognitive function. Participants had no evidence of any health disorders, were taking no medication, and were primarily normotensive. By means of principal components(More)
The anatomy and physiology of the retinotectal pathway of the perch was investigated using physiological and histological techniques. Massed responses of the optic nerve to single shocks exhibited five distinct peaks. Single-unit responses to shocks indicate two groups of fast fibers correlating well with peaks I and II of the massed response. The(More)
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