Domitille Pinot

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Appeared at the beginning of the 20th century, allergen-specific immunotherapy (SIT) has long been used in allergic rhinitis and asthma without any knowledge of its mechanisms of action or any tangible proof of its efficacy. However, from the beginning of the era of evidence-based medicine, a number of placebo-controlled studies have been published and(More)
BACKGROUND Asthma exacerbations represent the main source of costs and morbidity in asthma care, and drugs specifically designed to prevent exacerbations are needed. A prerequisite is to dispose of a precise knowledge of inflammatory events leading to exacerbations. OBJECTIVE To study T-cell activation during exacerbations from severe refractory(More)
This study investigated the relation between positive thyroid transcription factor 1 (TTF1) staining and survival of patients affected by primary adenocarcinoma (ADC) of the lung. Pathological tissue from consecutive ADC patients was collected from 2002 to 2004. The anti-TTF1 antibody (8G7G3/1, dilution of 1/200) was used. Thyroid transcription factor 1(More)
In this article a French working party critically review the international literature to revise the definition, pathophysiology, treatment and cost of exacerbations of adult asthma. The various guidelines do not always provide a consistent definition of exacerbations of asthma. An exacerbation can be defined as deterioration of clinical and/or functional(More)
There is no unequivocal definition of exacerbation in asthma. These are defined as episodes of increased or aggravated respiratory symptoms or as use of oral corticosteroid therapy. Viral infection is the most frequent cause of exacerbations. Inflammation during exacerbations is heterogeneous. It may be associated with bronchial hypereosinophilia, which is(More)
Laboratory examination included the following: white blood cell count 8.28 g?L with 43% neutrophils; haemoglobulin 16.3 g?L; haematocrit 47%; erythrocyte sedimentation rate 1 mm in the first h and C-reactive protein 1.55 mg?L. The results of renal function tests and biochemistry were within normal limits. Sputum specimens for culture and sensitivity and(More)
L’asthme professionnel dans l’industrie de la crevette, bien que peu documenté, est une entité classiquement décrite [1]. Les protéines de crevettes ont été identifiées comme étant à l’origine de cet asthme dont le mécanisme serait immunologique [2,3]. Toutefois, d’autres agents présents dans l’environnement professionnel, et notamment des irritants,(More)
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