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BACKGROUND Charcot-Marie-Tooth neuropathy has been reported to be associated with renal diseases, mostly focal segmental glomerulosclerosis (FSGS). However, the common mechanisms underlying the neuropathy and FSGS remain unknown. Mutations in INF2 were recently identified in patients with autosomal dominant FSGS. INF2 encodes a formin protein that interacts(More)
Long-term peritoneal dialysis (PD) is associated with alterations in peritoneal permeability and loss of ultrafiltration. These changes originate from increased peritoneal surface area, but the morphologic and molecular mechanisms involved remain unknown. The hypothesis that modifications of activity and/or expression of nitric oxide synthase (NOS) isozymes(More)
Water transport during peritoneal dialysis (PD) requires ultrasmall pores in the capillary endothelium of the peritoneum and is impaired in the case of peritoneal inflammation. The water channel aquaporin (AQP)-1 has been proposed to be the ultrasmall pore in animal models. To substantiate the role of AQP-1 in the human peritoneum, we investigated the(More)
OBJECTIVES Peritonitis due to peritoneal dialysis (PD) is best treated empirically while waiting for the results of the dialysate culture. Thus, antibiotic therapy must cover both gram-positive and gram-negative micro-organisms. First, over a period of 9 years in a multicenter study we evaluated the efficiency of a vancomycin and ciprofloxacin combination(More)
BACKGROUND AND OBJECTIVES Diagnosis of acute myocardial injury with biomarkers is difficult in patients with advanced renal failure. Circulating microRNAs are promising new biomarkers of myocardial injury. It is unknown whether levels of microRNAs are affected in patients undergoing hemodialysis. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS(More)
Sir, Interferon alfa (IFN-a) is a cytokine available for the treatment of malignant diseases and hepatitis B and C. Major complications of this drug include the occurrence of autoimmune disease w1x. Case. A 37-year-old woman undergoing haemodialysis (HD) in August 1983 following focal segmental glomerulosclerosis received a kidney donated by her father in(More)
In most cases, renal graft obstruction is caused by ureteral stenosis due to ischemia or technical error. Exceptional cases have been published where the obstacle was the result of incarceration of the ureter in an inguinal hernia. We report a case of this type, which prompt assessment was possible due to ultrasound and magnetic resonance imaging with 3D(More)