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Most chromosomal translocations in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) involve oncogenes that are either up-regulated or form part of new chimeric genes. The t(2;11)(p21;q23) translocation has been cloned in 19 cases of MDS and AML. In addition to this, we have shown that this translocation is associated with a strong(More)
This paper deals with a low complexity receiver scheme where equalization and channel decoding are jointly optimized in an iterative process. We derive the theoretical transfer function of the infinite length linear minimum mean square error (MMSE) equalizer with a priori information. A practical implementation is exposed which employs the Fast Fourier(More)
We propose and analyze a simple method to squeeze dynamically and unconditionally the collective spin of a dilute atomic ensemble by interaction with a driven mode of an optical resonator, as recently demonstrated [I. We show that substantial squeezing can be achieved in the regime of strong collective ensemble-resonator coupling. The squeezing is(More)
BRCA1-associated breast and ovarian cancer risks can be modified by common genetic variants. To identify further cancer risk-modifying loci, we performed a multi-stage GWAS of 11,705 BRCA1 carriers (of whom 5,920 were diagnosed with breast and 1,839 were diagnosed with ovarian cancer), with a further replication in an additional sample of 2,646 BRCA1(More)
Immuno-chemotherapy elicit high response rates in B-cell non-Hodgkin lymphoma but heterogeneity in response duration is observed, with some patients achieving cure and others showing refractory disease or relapse. Using a transcriptome-powered targeted proteomics screen, we discovered a gene regulatory circuit involving the nuclear factor CYCLON which(More)
Epigenetic perturbations are increasingly described in cancer cells where they are thought to contribute to deregulated gene expression and genome instability. Here, we report the first evidence that a distinct category of chromosomal translocations observed in human tumours--those targeting 1q12 satellite DNA--can directly mediate such perturbations by(More)
This paper investigates the realization of an efficient low-complexity turbo-equalizer under fixed-point data representation and computation constraints. We address the quantization issues that arise in the receiver design, and expose a simple computation procedure for the equalizer coefficients. The proposed solution is well-suited for a DSP implementation(More)
We describe the implementation of a low-complexity minimum mean-square error (MMSE) turbo-equalizer on Texas Instruments (TI) TMS320VC5509 device, a low-cost 16-bits fixed-point DSP typically designed for mobile terminals. A data rate of 207 Kb/s per iteration has been achieved. With carefully optimized data quantization, the resulting fixed-point receiver(More)