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AIM To analyse the immediate response of heart rate variability (HRV) in response to orthostatic stress in unexplained syncope. SUBJECTS 69 subjects, mean (SD) age 42 (18) years, undergoing 60 degrees head up tilt to evaluate unexplained syncope. METHODS Based on 256 second ECG samples obtained during supine and upright phases, spectral analyses of low(More)
OBJECTIVES This study sought to provide bedside evidence of the potential link between cardiac mitochondrial dysfunction and arrhythmia as reported in bench studies. BACKGROUND Atrial fibrillation (AF) is a frequent complication of cardiac surgery. Underlying mechanisms of post-operative atrial fibrillation (POAF) remain largely unknown. Because cardiac(More)
INTRODUCTION Inappropriate shocks remain a highly challenging complication of implantable cardioverter defibrillators (ICD). We examined whether automatic wireless remote monitoring (RM) of ICD, by providing early notifications of triggering events, lowers the incidence of inappropriate shocks. METHODS AND RESULTS We studied 433 patients randomly assigned(More)
The effect of methylphenidate on noradrenergic neurotransmission was investigated in urethane-anesthetized rats. The spontaneous activity of locus coeruleus noradrenergic neurons was the same in rats treated for 7 days with methylphenidate as in the controls. In control rats, i.v. methylphenidate induced a reduction of locus coeruleus neuronal firing(More)
BACKGROUND Previous studies have shown that investigation by tilt testing is very appropriate in paediatrics, but the characteristics of children and adolescents who are at high risk of recurrent syncope, once the diagnosis is established, remain unclear. This study was set up to analyse the risk factors attributed to syncope recurrence in paediatric(More)
UNLABELLED Preliminary studies have described, in young patients with unexplained cerebral infarction, electrophysiological abnormalities similar to those observed in paroxysmal atrial fibrillation. Moreover, in young adults with 'normal' hearts, increased susceptibility to paroxysmal atrial fibrillation with autonomic abnormalities as assessed by heart(More)
This pilot EEG mapping study was designed to explore thinking processes using complex mental imagery and thought processes. EEG was recorded with 19 electrodes (10/20 system against averaged ear lobe signals) while volunteers (n = 42) performed two separate tasks: visualization of an abstract concept and interpretation of a painting. Average spectral(More)
The maze test is a complex cognitive task involving visuoperceptual, planning and foresight abilities. EEGs were recorded from 20 healthy subjects according to the 10/20 system. Coherence is analogous to a correlation coefficient between the signals recorded by two electrodes and is computed between each electrode paired to all other electrodes. The maze(More)
BACKGROUND Endocarditis related to pacemaker (PM)-lead infection is a rare but serious complication of permanent transvenous pacing. To determine in which situations the diagnosis should be evoked and to determine optimal management, we reviewed our experience with endocarditis related to PM-lead infection. METHODS AND RESULTS Fifty-two patients were(More)