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Through evolution, enzymes have developed subtle modes of activation in order to ensure the sufficiently high substrate specificity required by modern cellular metabolism. One of these modes is the use of a target-dependent module (i.e. a docking domain) such as those found in signalling kinases. Upon the binding of the target to a docking domain, the… (More)

For a long time nucleic acid-based approaches directed towards controlling the propagation of Hepatitis C Virus (HCV) have been considered to possess high potential. Towards this end, ribozymes (i.e. RNA enzymes) that specifically recognize and subsequently catalyze the cleavage of their RNA substrate present an attractive molecular tool. Here, the unique… (More)

The HDV ribozyme's folding pathway is, by far, the most complex folding pathway elucidated to date for a small ribozyme. It includes 6 different steps that have been shown to occur before the chemical cleavage. It is likely that other steps remain to be discovered. One of the most critical of these unknown steps is the formation of the trans Watson-Crick GU… (More)

Dedicated to our friend and colleague George Stell. Abstract We study, via computer simulations, the fluctuations in the net electric charge, in a two dimensional one component plasma (OCP) with uniform background charge density −eρ, in a region Λ inside a much larger overall neutral system. Setting e = 1 this is the same as the fluctuations in N Λ , the… (More)

We have considered a system where the interaction, v(r)=v(IS)(r)+xi(2)v(MF)(r), is given as a linear combination of two potentials, each of which being characterized with a well-defined critical behavior: for v(IS)(r) we have chosen the potential of the restricted primitive model which is known to belong to the three-dimensional Ising universality class,… (More)

- J.-M Caillol, D Levesque, J.-J Weis
- 2002

Reassessment of the critical temperature and density of the restricted primitive mode of an ionic fluid by Monte Carlo simulations performed for system sizes with linear dimension up to L/σ = 34 and sampling of ∼ 10 9 trial moves leads to T * c = 0.04917 ± 0.00002 and ρ * c = 0.080 ± 0.005. Finite size scaling analysis based in the Bruce-Wilding procedure… (More)

- M Mazars, J-M Caillol, J-J Weis, D Levesque
- 2002

Using the specific model of a system of like charged ions confined between two planar like charged surfaces, we compare the predictions for the energy and density profile of four simulation methods available to treat the long range Coulomb interactions in systems periodic in two directions but bound in the third one. Monte Carlo simulations demonstrate… (More)

- E. Paschinger, D. Levesque, G. Kahl, J.-J. Weis
- 2001

– Our investigations of the phase diagram of a symmetric binary fluid in equilibrium with a porous matrix show that moderate changes in the properties of the matrix or in the matrix-fluid interaction lead to drastic modifications of the phase diagram of the fluid. Thus our results confirm on a qualitative basis recent experimental data. The phase diagrams… (More)

The phase behavior of a binary symmetric fluid in thermal equilibrium with a porous matrix has been studied with the optimized random phase approximation and grand canonical Monte Carlo simulations. Depending on the matrix properties and the matrix-fluid and fluid-fluid interactions we find three types of phase diagram characterized by a tricritical point,… (More)

Organoids have the potential to bridge 3D cell culture to tissue physiology by providing a model resembling in vivo organs. Long-term growing organoids were first isolated from intestinal crypt cells and recreated the renewing intestinal epithelial niche. Since then, this technical breakthrough was applied to many other organs, including prostate, liver,… (More)