Dominique Asselineau

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Glycation reaction is a recognized mechanism related to chronological aging. Previous investigations in cutaneous biology have considered the effect of glycation on the dermal matrix molecules, involved in tissue stiffening during skin aging. However, little is known about a possible direct effect of glycation upon cell differentiation. To address such(More)
The stimulation of prolylhydroxylase activity by ascorbate in IMR 90 fibroblasts grown as monolayer decreases with increasing population doubling level, but the enzyme is not stimulated in IMR 90 fibroblasts of either low or high population doubling level incorporated into collagen lattices in which they cease to divide. The capacity to be activated is(More)
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