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Fibronectin (FN) is secreted as a disulfide-bonded FN dimer. Each subunit contains three types of repeating modules: FN-I, FN-II, and FN-III. The interactions of alpha5beta1 or alphav integrins with the RGD motif of FN-III repeat 10 (FN-III10) are considered an essential step in the assembly of FN fibrils. To test this hypothesis in vivo, we replaced the(More)
We revisit the top-level ontology Gumo for the uniform management of user and context models in a semantic web environment. We discuss design decisions, while putting the focus on ontological issues. The structural integration into user model servers, especially into the U2M-UserModel&ContextService, is also presented. We show ubiquitous applications using(More)
Exploiting the rich traces of users' Web interaction promises to enable cross-application user modeling techniques, which is in particular interesting for applications that have a small user population or that are used infrequently. In this paper we present a framework for the effective interchange of user profiles. In addition to derivation rules for user(More)
This article summarizes research on several interrelated general issues that can arise in the design and development of user modeling systems: the learning and subsequent adaptation of general user models on the basis of empirical data; the model-ing of temporally variable properties of users, in particular time pressure and cognitive load; and the(More)
The rapid deployment of low-cost ubiquitous sensing devices – including RFID tags and readers, global positioning systems, wireless audio, video, and bio sensors – makes it possible to create instrumented environments and to capture the physical and communicative interaction of an individual with these environments in a digital register. One of the grand(More)