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Recombinant Adeno-associated virus vectors (rAAV) are widely used for gene delivery and multiple naturally occurring serotypes have been harnessed to target cells in different tissues and organs including the brain. Here, we provide a detailed and quantitative analysis of the transduction profiles of rAAV vectors based on six of the most commonly used(More)
Sensory cortices are commonly structured topographically; however, the extent to which this organization principle is preserved at the microcircuit level is debated. In this issue of Neuron, Issa et al. (2014) revisit this question by combining calcium imaging in awake mice at large scales encompassing the whole auditory cortex and small scales providing(More)
Most behaviors in mammals are directly or indirectly guided by prior experience and therefore depend on the ability of our brains to form memories. The ability to form an association between an initially possibly neutral sensory stimulus and its behavioral relevance is essential for our ability to navigate in a changing environment. The formation of a(More)
Population imaging in mouse auditory cortex revealed clustering of neural responses to brief complex sounds: the activity of a local population typically falls close to one out of a small number of observed states [1]. These clusters appear to group sets of auditory stimuli into a discrete set of activity patterns and could thereby form the basis for(More)
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