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The non-steroidal anti-inflammatory drugs, flufenamic acid, mefenamic acid and niflumic acid, block Ca2(+)-activated non-selective cation channels in inside-out patches from the basolateral membrane of rat exocrine pancreatic cells. Half-maximal inhibition was about 10 microM for flufenamic acid and mefenamic acid, whereas niflumic acid was less potent(More)
Service-oriented computing is becoming an increasingly popular paradigm for modelling and building distributed systems in open and heterogeneous environments. However, proposed service-oriented ar-chitectures are typically based on centralised components , such as service registries or service brokers, that introduce reliability, management, and performance(More)
Human dynamics are inextricably intertwined with the social, geographical and economic environment. The continuous flux of people communicating as well as migrating, commuting, and traveling inevitably spans acquaintances across geographic space that is far from random and exhibits regular patterns. For instance, it has been shown that the probability of(More)
Software license management is currently expanding from its traditional desktop environment into the mobile application space, but software vendors are still applying old licensing models to a platform where application rights will be specified, managed and distributed in new and different ways. This paper presents an open-source pervasive application(More)
The assumption of the availability of port information at design time of service compositions in Service-Oriented Architectures (SOAs) is not valid for an increasing number of hosts on the Internet that do not have a public, static IP address. Existing workflow engines do not support services deployed on such hosts, as service invocations require the(More)
The ability to intervene in disease progression given a person's disease history has the potential to solve one of society's most pressing issues: advancing health care delivery and reducing its cost. Controlling disease progression is inherently associated with the ability to predict possible future diseases given a patient's medical history. We invoke an(More)
abstraCt Many recently emerging component-based Web portal application platforms allow end users to compose dynamic Web dialogues on the fly. Experts predict that this paradigm will enable a class of new applications for Web-based content delivery in information-rich, agile business domains, such as health care. We present a conceptual analysis of the(More)