Dominick Coleman

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This report describes the development of obesity syndromes in mice caused by two autosomal recessive mutations, fat (fat), located on chromosome 8, and tubby (tub), located on chromosome 7. Both mutations cause slowly developing but ultimately severe obesity conditions. Although hyperinsulinemia, hyperactivity of the beta cell of the islets of Langerhans,(More)
A polygenic basis for susceptibility to insulin-dependent diabetes in nonobese diabetic (NOD) mice has been established by outcross to a related inbred strain, nonobese normal (NON). Analysis of first and second backcross progeny has shown that at least three recessive genes are required for development of overt diabetes. One, Idd-1s, is tightly linked to(More)
The aim of this study was to identify if an inverse relationship exists between Gross Efficiency (GE) and V˙O2max in trained cyclists. In Experiment 1, 14 trained cyclist's GE and V˙O2max were recorded at 5 different phases of a cycling 'self-coached' season using an incremental laboratory test. In Experiment 2, 29 trained cyclists undertook 12 weeks of(More)
The effects of aging and diabetes on the uptake and incorporation of [3H]estradiol (E) in various brain areas was analyzed in C57BL/KsJ mice. Control (C; +/?) and diabetic (D; db/db) mice were pulse treated (30 min) with 10 muCi of [3H]E at 1, 2 and 4 months of age and the brains were subsequently microdissected, digested and the amount of incorporated(More)
The effects of diabetes on the age-related changes in glucose utilization by various brain regions were examined in genetically diabetic (db/db) and normal (+/?) C57BL/KsJ mice following a 10 muCi injection of [3H]2-deoxyglucose (2-DOG). Brains were collected from 2 to 16-week-old mice at 30 min postinjection with 2-DOG, and the brain regions isolated by(More)
Objective: To determine the efficacy of post-operative pain control over the first 24 hours in patients undergoing unilateral total knee arthroplasty (TKA) using a multi-modal analgesia protocol including femoral nerve catheters (FNC). Materials and Methods: 119 patients who underwent unilateral TKA between 2009 and 2010 under regional anesthesia with FNC(More)
Transcription of early growth response gene-1 (Egr-1) is required for macrophage differentiation. Since granulocyte-macrophage colony-stimulating factor (GM-CSF) induces macrophage proliferation as well as the transcription of Egr-1 mRNA, we characterized the induction of Egr-1 protein in murine peritoneal macrophages following treatment with GM-CSF. As(More)
The nature of the genetic defects which define the obese (ob) and diabetes (db) loci in mice remain unknown, but both produce similar syndromes when maintained in the same strain of mice. There is some evidence suggesting a lesion in the central nervous system (CNS) in db/db mice, while ob/ob mice appear to have a primary lesion outside the CNS. In a search(More)