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Using chemical reactions and diffusion to control pattern formation requires the careful design of reaction networks and a balance of kinetics that is difficult to achieve. Now, it has been shown that DNA-based reaction networks provide a robust method for transforming patterns.
Cells use sophisticated, multiscale spatial patterns of chemical instructions to control cell fate and tissue growth. While some types of synthetic pattern formation have been well studied 1–6 , it remains unclear how to design chemical processes that can reproducibly create similar spatial patterns. Here we describe a scalable approach for the design of… (More)
Chemical reactions and diffusion can produce a wide variety of static or transient spatial patterns in the concentrations of chemical species. Little is known, however, about what dynamical patterns of concentrations can be reliably programmed into such reaction–diffusion systems. Here we show that given simple, periodic inputs, chemical reactions and… (More)
Chemical circuits can coordinate elaborate sequences of events in cells and tissues, from the self-assembly of biological complexes to the sequence of embryonic development. However, autonomously directing the timing of events in synthetic systems using chemical signals remains challenging. Here we demonstrate that a simple synthetic DNA strand-displacement… (More)