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Population Pharmacokinetics and Clinical Response for Artemether-Lumefantrine in Pregnant and Nonpregnant Women with Uncomplicated Plasmodium falciparum Malaria in Tanzania
TLDR
The observed reduction in the relative bioavailability of lumefantrine in pregnant women may explain the higher treatment failure in this group, mostly due to lower posttreatment prophylaxis. Expand
Trends in chloroquine resistance marker, Pfcrt-K76T mutation ten years after chloroquine withdrawal in Tanzania
TLDR
CQ withdrawal in Tanzania has resulted into >90% recovery of susceptibility in ten years of withdrawal, which is in support of the search for CQ-based combination drugs as a possible future alternative to SP for IPTp in places where full recovery of C Q-susceptibility will be evident. Expand
Levels and correlates of non-adherence to WHO recommended inter-birth intervals in Rufiji, Tanzania
TLDR
Generally, one in every two inter-birth intervals among 15–49 year-old women in Rufiji district is poorly spaced, with significant variations by socio-demographic and behavioral characteristics of mothers and newborns. Expand
Bacterial Contamination of Medical Doctors and Students White Coats at Kilimanjaro Christian Medical Centre, Moshi, Tanzania
TLDR
White coats are potential source of cross infection which harbour bacterial agents and may play a big role in the transmission of nosocomial infection in health care settings and effort should be made to discourage usage of white coats outside clinical areas. Expand
First-trimester artemisinin derivatives and quinine treatments and the risk of adverse pregnancy outcomes in Africa and Asia: A meta-analysis of observational studies
TLDR
The benefits of 3-d artemisinin combination therapy regimens to treat malaria in early pregnancy are likely to outweigh the adverse outcomes of partially treated malaria, which can occur with oral quinine because of the known poor adherence to 7-d regimens. Expand
Carriage of penicillin-non-susceptible pneumococci among children in northern Tanzania in the 13-valent pneumococcal vaccine era.
TLDR
Penicillin non-susceptibility in S. pneumoniae colonizing Tanzanian children increased during an observation period shortly after the introduction of PCV13, and measures to ensure rational use of antibiotics and more effective systems for surveillance of antibiotic resistance and serotype distribution are needed to assure continued effective treatment of pneumococcal disease. Expand
Maternal and obstetric risk factors associated with preterm delivery at a referral hospital in northern-eastern Tanzania
TLDR
Clinicians and other health care providers should routinely assess women at high risk of pre term delivery during prenatal care to prevent the occurrence of preterm delivery and associated adverse perinatal outcomes. Expand
Factors associated with management of cervical cancer patients at KCMC Hospital, Tanzania: a retrospective cross-sectional study
TLDR
Most of cervical cancer patients at KCMC are seen at late stage necessitating referral for radiotherapy, chemotherapy or palliative care, which may reflect lack of cervical screening in order to early detect and treat pre-malignant disease stage. Expand
Safety of artemether-lumefantrine exposure in first trimester of pregnancy: an observational cohort
TLDR
It is likely that the effect observed was related to the drug and not to the disease itself, and a change of policy from quinine to AL for the treatment of uncomplicated malaria during the whole pregnancy period could be already envisaged. Expand
Quality of paediatric blood transfusions in two district hospitals in Tanzania: a cross-sectional hospital based study
TLDR
Criteria for BT are not always fulfilled; time to initiate and complete the transfusion is often unacceptable long and monitoring of vital signs during BT is poor; it is recommended that an external supervision system be established to monitor and evaluate the quality of BT performance in the laboratories as well as in wards. Expand
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