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  • Ganesh M. Shankar, Brenda L Bloodgood, Matthew Townsend, Dominic M Walsh, Dennis J Selkoe, Bernardo L. Sabatini
  • Biology, Medicine
  • The Journal of Neuroscience
  • 2007 (First Publication: 14 March 2007)
  • Alzheimer's disease (AD) is characterized by decreased synapse density in hippocampus and neocortex, and synapse loss is the strongest anatomical correlate of the degree of clinical impairment.Expand
  • Shaomin Li, Soyon Hong, Nina E. Shepardson, Dominic M Walsh, Ganesh M. Shankar, Dennis J Selkoe
  • Medicine, Biology
  • Neuron
  • 2009 (First Publication: 1 June 2009)
  • In Alzheimer's disease (AD), the impairment of declarative memory coincides with the accumulation of extracellular amyloid-beta protein (Abeta) and intraneuronal tau aggregates. Dementia severityExpand
  • Matthew Townsend, Ganesh M. Shankar, Tapan H. Mehta, Dominic M Walsh, Dennis J Selkoe
  • Chemistry, Medicine
  • The Journal of physiology
  • 2006 (First Publication: 1 April 2006)
  • The accumulation of amyloid beta-protein (Abeta) in brain regions serving memory and cognition is a central pathogenic feature of Alzheimer's disease (AD). We have shown that small soluble oligomersExpand