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Providers of products and services are faced with the dual challenge of supporting the languages and individual needs of the global customer while also accommodating the increasing relevance of user-generated content. As a result, the content and localisation industries must now evolve rapidly from manually processing predicable content which arrives in(More)
Androgen receptor variants (AR-Vs) provide a mechanism of therapy evasion in castrate-resistant prostate cancer (CRPC), yet mechanisms of regulation remain largely unknown. Here we investigate the role of Aurora A kinase on AR-Vs in models of CRPC and show depletion of Aurora A reduces AR-V target gene expression. Importantly, knockdown of Aurora A(More)
Endocrine therapy has successfully been used to treat estrogen receptor (ER)-positive breast cancer, but this invariably fails with cancers becoming refractory to treatment. Emerging evidence has suggested that fluctuations in ER co-regulatory protein expression may facilitate resistance to therapy and be involved in breast cancer progression. To date, a(More)
This paper defines and discusses the implementation of two novel extensions to the Siena Content-based Network (CBN) to extend it to become a Knowledge-based Network (KBN) thereby increasing the expressiveness and flexibility of its publications and subscription. One extension provides ontological concepts as an additional message attribute type, onto which(More)
The importance of the estrogen receptor (ER) in breast cancer (BCa) development makes it a prominent target for therapy. Current treatments, however, have limited effectiveness, and hence the definition of new therapeutic targets is vital. The ER is a member of the nuclear hormone receptor superfamily of transcription factors that requires co-regulator(More)
The androgen receptor (AR) is a key molecule involved in prostate cancer (PC) development and progression. Post-translational modification of the AR by co-regulator proteins can modulate its transcriptional activity. To identify which demethylases might be involved in AR regulation, an siRNA screen was performed to reveal that the demethylase, KDM4B, may be(More)
The fossil record has been interpreted as exhibiting a gradual decrease in the extinction rate. We use the individual based Tangled Nature model of evolutionary ecology to study the mechanisms behind this kind of nonstationary macrodynamics. We demonstrate that the long time aging in the system (manifested as a slowing down of the rate of large jumps, or(More)
Users of the web are increasingly interested in tracking the appearance of new postings rather than locating existing knowledge. Coupled with this is the emergence of the Web 2.0 movement (where everyone effectively publishes and subscribes), and the concept of the "Internet of Things". These trends bring into sharp focus the need for efficient distribution(More)