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OBJECTIVE To assess the clinical course and genotype-phenotype correlations in patients with selenoprotein-related myopathy (SEPN1-RM) due to selenoprotein N1 gene (SEPN1) mutations for a retrospective cross-sectional study. METHODS Forty-one patients aged 1-60 years were included. Clinical data including scoliosis, respiratory function, and growth(More)
Cuticular components of the green leaves of the Repandae section of theNicotiana species contain compounds that have been shown to be toxic to larvae of the tobacco hornworm larvae,Manduca sexta. The surface constituents of leaves of greenhouse-grownN. repanda, N. stocktonii, andN. nesophila were extracted with methylene chloride in order to isolate the(More)
Providers of products and services are faced with the dual challenge of supporting the languages and individual needs of the global customer while also accommodating the increasing relevance of user-generated content. As a result, the content and localisation industries must now evolve rapidly from manually processing predicable content which arrives in(More)
SUMMARY As tibial intramedullary nailing becomes the preferred treatment for tibial shaft fracture, removal of tibial nails will become more common. Removal of tibial intramedullary nails is not without complications, but a review of the literature found only one recent report of a fracture of the tibia during removal. A case report of a tibial fracture(More)
In a randomised prospective trial 98 elderly women with trochanteric fractures of the femur were treated with either a 135 degrees Jewett nail-plate or a 135 degrees Dynamic hip screw. The results at six weeks, three months and six months were statistically analysed. There were no significant differences in the two groups with regard to pain, length of(More)
BACKGROUND Resistance and susceptibility to scrapie has been associated with single nucleotide polymorphisms located within codons 136, 154 and 171 of the ovine prion protein gene (PRNP). Dual-labelled HyBeacon probes were developed to analyse single and clustered polymorphisms within these and neighbouring codons. METHODS Extracted DNAs and unpurified(More)
Between January 1977 and January 1988, 19 patients with non-Hodgkin's lymphoma (NHL) involving the ileocaecal region were cared for by the CRC Wessex Medical Oncology Unit. Fifteen of these patients had primary ileocaecal NHL (stages IE or IIE) and four had secondary involvement of this region (stage IV). The commonest clinical presentation was with(More)
This paper defines and discusses the implementation of two novel extensions to the Siena Content-based Network (CBN) to extend it to become a Knowledge-based Network (KBN) thereby increasing the expressiveness and flexibility of its publications and subscription. One extension provides ontological concepts as an additional message attribute type, onto which(More)