Dominic Berges

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SK&F 75073, a new parenteral cephalosporin, was found to have broad in vitro and in vivo antibacterial activity including isolates usually resistant to cephalothin and cefazolin. This activity included indole-positive Proteus and Enterobacter species and some Serratia isolates. Proteus mirabilis strains were particularly susceptible, as were Haemophilus(More)
Sulfanilic acid, in contrast to sulfanilamide, has poor in vitro antibacterial activity. Paradoxically, it has been shown to be a more effective inhibitor than sulfanilamide of dihydropteroic acid synthase. In order to circumvent the presumed permeability barrier to sulfanilic acid, advantage was taken of the technique of portage transport. Derivatives of(More)
Cyclic and acyclic analogs of tetrahydrodipicolinate (THDPA) are evaluated in a study of the active site of succinyl-CoA:tetrahydrodipicolinate N-succinyltransferase. In addition to the natural substrate, THDPA, one cyclic and several acyclic compounds are also succinylated. 2-Hydroxytetrahydropyran-2,6-dicarboxylic acid is a potent competitive inhibitor(More)
Succinyl-CoA:tetrahydrodipicolinate-N-succinyltransferase is a key enzyme in the biosynthesis of diaminopimelic acid (DAP), a component of the cell wall peptidoglycan of nearly all bacteria. This enzyme converts the cyclic precursor tetrahydrodipicolinic acid (THDPA) to a succinylated acyclic product. L-2-Aminopimelic acid (L-1), an acyclic analogue of(More)
This paper presents the design and evaluation of a ΣΔ-modulator based analog-to-digital converter (ADC) for direct RF digitization within a multi-standard vehicular connectivity architecture. Upcoming trends and changes which will require new architecture concepts for connectivity in the automotive domain are discussed. Hardware requirements are derived.(More)
Cefatrizine (SK&F 60771), a new orally-active semisynthetic cephalosporin antibiotic with broad-spectrum antibacterial activity, was compared with cephalexin and cefazolin for in vitro and in vivo antibacterial activity and pharmacokinetic behavior in laboratory animals. The average MIC values obtained with cefatrizine against gram-positive and(More)
A nonhydrolyzable analogue of ubiquitin adenylate has been synthesized for use as a specific inhibitor of the ubiquitination of proteins. Ubiquitin adenylate is a tightly bound intermediate formed by the ubiquitin activating enzyme. The inhibitor adenosyl-phospho-ubiquitinol (APU) is the phosphodiester of adenosine and the C-terminal alcohol derived from(More)
Rapid developments and emergence of diverse wireless systems call for radio frontends with agile and multistandard properties. Within this publication the performance of a direct RF digitizing ΣΔ-modulator based analog-to-digital converter (ADC) is evaluated based on orthogonal frequency division multiplex (OFDM) system simulation on the bitstream layer.(More)
  • Dominic Berges
  • Pflüger's Archiv für die gesamte Physiologie des…
  • 2004
An 10 gesunden Sportstudenten wurde der Tagesgang der Muskelaktivität an der mittleren Amplitude der Muskelaktionspotentiale verfolgt. Im Vordergrund der Tagesschwankungen fand sich eine 12stündige Periodik, die sich bezüglich Phasenlage und Amplitude weitgehend wie entsprechende Tageskurven anderer Organfunktionen verhielt. Zwischen Tagesmittelwert(More)