Domingos Alves

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We extend the deterministic population genetics formulation of the qua-sispecies model [Phys. Rev. E 54, 4048 (1996)] to finite populations in order to investigate analytically the dependence of the error threshold on the population size. In particular, we find that for large populations the repli-cation accuracy at the threshold increases linearly with the(More)
The effects of error propagation in the reproduction of diploid organisms are studied within the population genetics framework of the quasis-pecies model. The dependence of the error threshold on the dominance parameter is fully investigated. In particular, it is shown that dominance can protect the wild-type alleles from the error catastrophe. The analysis(More)
BACKGROUND The partograph is currently the main tool available to support decision-making of health professionals during labour. However, the rate of appropriate use of the partograph is disappointingly low. Apart from limitations that are associated with partograph use, evidence of positive impact on labour-related health outcomes is lacking. The main goal(More)
The proposal of new analytical techniques has guided innovative methodological developments in public health interventions. The goal of this work is show advances in the development of a large scale system for space-time visualization, monitoring, modeling and analysis of epidemic data using a Grid platform. The resulting virtual laboratory, dubbed(More)
The idea of this review is to connect the different models of evolution to those of biological ageing through Darwin's theory. We start with the Eigen model of quasis-pecies for microevolution, then introduce the Bak-Sneppen model for macroevolu-tion and, finally, present the Penna model for biological ageing and some of its most important results. We also(More)
A population genetics formulation of Eigen's molecular quasis-pecies model [Naturwissenchaften 58, 465 (1971)] is proposed and several simple replication landscapes are investigated analytically. Our results show a remarkable similarity to those obtained with the original kinetics formulation of the quasispecies model. However, due to the simplicity of our(More)
OBJECTIVE to develop a mobile app for research on the use of tobacco among psychiatric patients and the general population. METHOD applied research with the technological development of an app for data collection on an Android tablet. For its development, we considered three criteria: data security, benefits for participants and optimization of the time(More)