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We extend the deterministic population genetics formulation of the qua-sispecies model [Phys. Rev. E 54, 4048 (1996)] to finite populations in order to investigate analytically the dependence of the error threshold on the population size. In particular, we find that for large populations the repli-cation accuracy at the threshold increases linearly with the(More)
A population genetics formulation of Eigen's molecular quasis-pecies model [Naturwissenchaften 58, 465 (1971)] is proposed and several simple replication landscapes are investigated analytically. Our results show a remarkable similarity to those obtained with the original kinetics formulation of the quasispecies model. However, due to the simplicity of our(More)
BACKGROUND The partograph is currently the main tool available to support decision-making of health professionals during labour. However, the rate of appropriate use of the partograph is disappointingly low. Apart from limitations that are associated with partograph use, evidence of positive impact on labour-related health outcomes is lacking. The main goal(More)
This work presents the architecture of a data access and integration service dedicated to epidemic monitoring and execution of epidemic simulations dubbed grid integration service (GISE). GISE is a flexible service built on Globus 4 grid infrastructure. Its architecture uses mediators, wrappers and canonic data models to perform queries on geographically(More)
The proposal of new analytical techniques has guided innovative methodological developments in public health interventions. The goal of this work is show advances in the development of a large scale system for space-time visualization, monitoring, modeling and analysis of epidemic data using a Grid platform. The resulting virtual laboratory, dubbed(More)
This paper presents a service related to epidemiologic monitoring providing a database of maps, synthetics graphs, and spatial-temporal information of a particular disease enriched with demographic data and urban georeferenced structure. The proposed service is to be used for Brazilian health agencies and the involved metropolitan authorities which will(More)
Dengue fever is a flu-like illness characterized by symptoms such as high fever, severe headache, pain behind the eyes, muscle and joint pains, and rash. The virus is transmitted via the bite of various day-feeding mosquitoes (e.g. Aedes aegypti). Dengue constitutes one of the most important re-emergent disease in America. In the last decade, there were an(More)