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Hepatocellular carcinoma (HCC) is a frequent form of cancer with a poor prognosis and with limited possibilities for medical intervention. Recent evidence has accumulated that long noncoding RNAsContinue Reading
In response to DNA damage, transcription is blocked by inhibition of RNA polymerase II activity. The regulation of a preexisting pool of mRNAs, therefore, plays a key role in DNA repair, cell cycleContinue Reading
  • Alexandra Koch, Shashank Saran, +7 authors Teruko Tamura
  • Biology, Medicine
  • Cell Communication and Signaling
  • 2014 (First Published: 1 December 2014)
  • BackgroundOne of the most insidious characteristics of cancer is its spread to and ability to compromise distant organs via the complex process of metastasis. Communication between cancer cells andContinue Reading
  • Doan Duy Hai Tran, Alexandra Koch, +5 authors Teruko Tamura
  • Biology, Medicine
  • Cellular signalling
  • 2016 (First Published: 1 December 2016)
  • Over 100 putative driver genes that are associated with multiple recurrently altered pathways were detected in hepatocellular carcinoma (HCC), suggesting that multiple pathways will need to beContinue Reading
  • Doan Duy Hai Tran, Alexandra Koch, +9 authors Teruko Tamura
  • Biology, Medicine
  • Cellular signalling
  • 2016 (First Published: 1 May 2016)
  • Differentiated hepatocytes are long-lived and normally do not undergo cell division, however they have the unique capacity to autonomously decide their replication fate after liver injury. In thisContinue Reading