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Rats received a unilateral lesion of the nucleus basalis by infusion of ibotenic acid. Two weeks after the lesion, osmotic minipumps were implanted, that infused 1 microgram human recombinant nerve growth factor (NGF) or cytochrome-C per day into the lateral ventricle. After four weeks of treatment, release of acetylcholine was measured in the frontal(More)
Fisher 344 rats underwent bilateral nucleus basalis magnocellularis (NBm) lesioning followed by testing in a delayed nonmatching-to-sample T-maze task. Both lesion and control animals acquired the task although the NBm animals were mildly impaired on acquisition and on trials to criterion. Increasing the delay reduced accuracy of performance equally in both(More)
Hitherto, morphological changes seen in mitochondria obtained from samples of skeletal muscle in a variety of neuromuscular disorders have not been correlated with functional abnormalities and so have not been considered significant for the pathogenesis of these conditions. But more recently, investigators from Cornell University have linked these same(More)
DOI 10.1007/s00115-009-2779-0 © Springer Medizin Verlag 2009 E. Wicklein1 · D. Langdon2 · N. Prayoonwiwat3 · P. Scherer 4 · U.K. Zettl 5 · S. Fredrikson6 1 Bayer Schering Pharma AG, Berlin 2 Royal Holloway, University of London, London 3 Department of Medicine, Siriraj Hospital Mahidol University, Bangkok 4 Kantstraße, Berlin 5 Klinik für Neurologie und(More)
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