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It is proposed that the plasma membrane in the active zones of synaptic terminals contains self-assembling cooperative domains whose Ca2+-induced solidification may be the driving force of the fast neurotransmitter release in the central synapses. This hypothesis and a qualitative model of the phase-transition-driven exocytosis provide formulation of a(More)
Temperature as a regulator of sleep is considered. Phenomenological data are presented indicating that there is a causal (not just a correlative) relationship between the changes in brain temperature and sleep phases in the wake-sleep cycle. An earlier suggested phase-transitional concept of the recovery function of sleep was shown to be the theoretical(More)
A kinetic lattice model of chain-melting phase transition has been developed. Its time scale has been calibrated with the acoustic relaxation spectroscopic data. The model presents a tool for the analysis and predictions of kinetic features of those physiological processes in biological membranes whose mechanism is based on the phase transition in the lipid(More)
Differential microcalorimetric measurements have been performed in aqueous dispersions of dimyristoylphosphatidylcholine (DMPC) multilamellar vesicles in a wide range of temperatures covering the whole transition between the lamellar gel and lamellar fluid states (the chain-melting/ordering transition). The shape of calorimetric curves was analyzed in a(More)
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