Dmitry Moshkoff

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Lassa virus (LASV) and Mopeia virus (MOPV) are closely related Old World arenaviruses that can exchange genomic segments (reassort) during coinfection. Clone ML29, selected from a library of MOPV/LASV (MOP/LAS) reassortants, encodes the major antigens (nucleocapsid and glycoprotein) of LASV and the RNA polymerase and zinc-binding protein of MOPV.(More)
Lassa hemorrhagic fever (LHF) is a rodent-borne viral disease that can be fatal for human beings. In this study, an attenuated Lassa vaccine candidate, ML29, was tested in SIV-infected rhesus macaques for its ability to elicit immune responses without instigating signs pathognomonic for arenavirus disease. ML29 is a reassortant between Lassa and Mopeia(More)
Viral infections are the main cause of disease in the world, with the respiratory diseases being the main cause of morbidity. The arenaviruses are zoonotic pathogens transmitted from rodents to humans, and are the cause of flu-like disease that can rapidly develop into fatal hemorrhagic fevers. The respiratory diseases and in particular those produced by(More)
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