Dmitry Izotov

Learn More
The protein backbone is described as a smooth curved and twisted line in three-dimensional (3D) space and characterized by its curvature κ and torsion τ both expressed as a function of arc length s. It is shown that the function τ(s) is sufficient to analyze the contributions of all amino acids to the conformation of the protein backbone. The characteristic(More)
A new method for the Automated Protein Structure Analysis (APSA) is derived, which simplifies the protein backbone to a smooth curve in 3-dimensional space. For the purpose of obtaining this smooth line each amino acid is represented by its C α atom, which serves as suitable anchor point for a cubic spline fit. The backbone line is characterized by arc(More)
The Automated Protein Structure Analysis (APSA) method, which describes the protein backbone as a smooth line in three-dimensional space and characterizes it by curvature kappa and torsion tau as a function of arc length s, was applied on 77 proteins to determine all secondary structural units via specific kappa(s) and tau(s) patterns. A total of 533(More)
The Automated Protein Structure Analysis (APSA) method is used for the classification of supersecondary structures. Basis for the classification is the encoding of three-dimensional (3D) residue conformations into a 16-letter code (3D-1D projection). It is shown that the letter code of the protein makes it possible to reconstruct its overall shape without(More)
  • 1