Dmitrii V. Kurilov

  • Citations Per Year
Learn More
The composition of essential oil of Artemisia lerchiana Web. plants growing in Volgograd oblast was studied. Sampling was performed from plots contrasting in climatic and soil characteristics. Essential oil was obtained by hydrodistillation. The content of essential oil in shoot biomass increased gradually during shoot formation, flower bud formation, and(More)
A series of dipeptide mimetics of nerve growth factor were synthesized, one of which, bis-(monosuccinyl-Lglutamyl-L-lysine) hexamethylenediamide (GK-2), constructed on the basis of the β-turn of its fourth loop, was selected for development as a potential neuroprotective drug. This study describes the first phase in the creation of a technology for(More)
In the previous work, we synthesized a dimeric dipeptide mimetic of the 4th loop of BDNF, i.e., hexamethylenediamide bis(N-monosuccinil-L-seryl-L-lysine) (GSB-106), which has neuroprotective activity in vitro in a concentration range of 10−5–10−8 M and antidepressant activity in vivo at intraperitoneal doses of 0.1 and 1 mg/kg in rats. We studied the(More)
The investigation was undertaken to study the biology and ecology of Latrodectus, the possibilities of its importation to Russia from other countries, to breed Latrodectus in the laboratory setting, and to design the first homeopathic matrix of Latrodectus to manufacture homeopathic remedies. The authors were the first to devise a method for Latrodectus(More)
Experiments were carried out on 35 lambs infected with echinococcus eggs taken from canine donors, 5 lambs with echinococcosis, 5 lambs with echinococcosis + paecilomycosis, 5 lambs with coenurosis, 5 with cysticercosis ovis, 5 with alveococcosis, 5 with paecilomycosis, inoculated by the material taken from patients; and 5 healthy lambs formed a control(More)
The data on the geological structure of the western Kamchatka were first obtained by the geologist M.F. Dvali (All-Russia Oil Research Geological Prospecting Institute) in 1932 [6]. He discovered Cretaceous beds in this area and determined the widespread volcanites as the Kinkil’skii Mys Formation. To the north of the mouth of the Palana River, he(More)
The BDNF-mimetic dimeric dipeptide bis-(N-monosuccinyl-L-seryl-L-lysine) hexamethylenediamide (GSB-106) based on the structure of beta-turn loop 4 (BDNF-Asp93-Ser94-Lys95-Lys96-) was synthesized. GSB-106 showed neuroprotective activity in vitro at concentrations 10–6-10–8 M and antidepressant activity in vivo in rats at i.p. injected doses of 0.1-1 mg/kg.(More)
In previous work we have obtained a dimeric dipeptide mimetic of 4th loop of BDNF - hexamethylenediamide bis-(N-monosuccinil-L-seryl-L-lysine) (GSB-106), having a neuroprotective activity in vitro in a concentration range 10(-5)-10(-8) M and an antidepressant activity in vivo at doses 0.1 and 1 mg/kg i.p. in rats. We have investigated the structural and(More)
538 Mint is the key medicinal and essential oil produc ing plant. Much attention is given in many countries to the development of biological bases of mint cultivation and innovative technologies of mint reproduction and transformation [1, 2]. However, the physiological determinants of realization of adaptive and productive potentials remain insufficiently(More)
The authors have detected atypical paecilomycosis-associated myocarditis with impaired amino acid exchange and pain syndrome for the first time. At first, pain occurs in the chest and radiates into the axilla, to the left arm to the finger tips, by paralyzing the arm. In some patients, pain manifests itself in both arms with radiation to the belly, by(More)