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There has been great interest recently in the use of designed experiments to improve quality by reducing the variation of industrial products. A major stimulus has been Taguchi’s robust design scheme, in which experiments are used to detect factors that affect process variation. We study here one of Taguchi’s novel ideas, the use of noise factors to(More)
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Glatiramer acetate (GA), the active ingredient in Copaxone®, is a complex mixture of polypeptides used for the treatment of relapsing remitting multiple sclerosis. Glatiramoids are related mixtures that may differ in some characteristics of the prototype molecule. Our aim is to describe the long-term toxicity studies with protiramer (TV-5010), a new(More)
The Borg Ratings of Perceived Exertion scale (RPE) has been shown to be a valuable tool for prescribing exercise; however, use of RPE-based exercise prescriptions in field settings has often been problematic because RPE data derived from maximal exercise testing are needed. We describe a simple method for obtaining target RPEs for exercise training from(More)
For patient populations whose heart rates cannot be used to regulate exercise intensity, the Borg Rating of Perceived Exertion (RPE) Scale is the preferred way to prescribe exercise intensity. Individual perceptual variations are best quantified by measuring perceptual intensity during maximal exercise testing; however, many situations require a submaximal(More)
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