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HSV ICP0 recruits USP7 to modulate TLR-mediated innate response.
Pattern recognition receptors represent the first line of defense against invading pathogens. Herpes simplex virus (HSV) encodes multiple ligands detected by these receptors, yet persists in theExpand
Proteolytic Processing Regulates Toll-like Receptor 3 Stability and Endosomal Localization*
Background: Whether TLR3 requires proteolytic processing is not clear. Results: TLR3 was found to be processed by cathepsins within Loop1 of leucine-rich repeat 12. Proteolytic processing is notExpand
LL-37 Peptide Enhancement of Signal Transduction by Toll-like Receptor 3 Is Regulated by pH
Background: How LL-37 delivers double-stranded RNA (dsRNA) to activate TLR3 signaling is poorly understood. Results: LL-37 was found to traffic to endosomes with RNA and releases the dsRNA uponExpand
The Human Antimicrobial Peptide LL-37, but Not the Mouse Ortholog, mCRAMP, Can Stimulate Signaling by Poly(I:C) through a FPRL1-dependent Pathway*
Background: How the cathelicidin LL-37 enhances Toll-like receptor 3 signaling is poorly understood. Results: We determined that LL-37-poly(I:C) complex can localize to early endosomes with TLR3Expand
MAPK and heat shock protein 27 activation are associated with respiratory syncytial virus induction of human bronchial epithelial monolayer disruption.
Respiratory syncytial virus (RSV) is the major cause of bronchiolitis in infants, and a common feature of RSV infections is increased lung permeability. The accumulation of fluid in the infectedExpand
Signal Transduction and Intracellular Trafficking by the Interleukin 36 Receptor*
Background: Signaling by the IL-36 receptor is poorly characterized. Results: Activation of IL-36R signaling is coupled with its endocytosis to lysosomes. Tollip mediates IL-1 receptor turnover andExpand
Molecular analysis of a UDP-GlcNAc:polypeptide alpha-N-acetylglucosaminyltransferase implicated in the initiation of mucin-type O-glycosylation in Trypanosoma cruzi.
Trypanosoma cruzi, the causative agent of Chagas disease, is surrounded by a mucin coat that plays important functions in parasite survival/invasion and is extensively O-glycosylated by Golgi andExpand
Absence of Grail promotes CD8+ T cell anti-tumour activity
T-cell tolerance is a major obstacle to successful cancer immunotherapy; thus, developing strategies to break immune tolerance is a high priority. Here we show that expression of the E3 ubiquitinExpand
Targeting the Src Homology 2 (SH2) Domain of Signal Transducer and Activator of Transcription 6 (STAT6) with Cell-Permeable, Phosphatase-Stable Phosphopeptide Mimics Potently Inhibits Tyr641
Signal transducer and activator of transcription 6 (STAT6) transmits signals from cytokines IL-4 and IL-13 and is activated in allergic airway disease. We are developing phosphopeptide mimeticsExpand
Prolyl hydroxylation- and glycosylation-dependent functions of Skp1 in O2-regulated development of Dictyostelium.
O(2) regulates multicellular development of the social amoeba Dictyostelium, suggesting it may serve as an important cue in its native soil environment. Dictyostelium expresses an HIFα-type prolylExpand