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We describe predictions made using the Rosetta structure prediction methodology for both template-based modeling and free modeling categories in the Seventh Critical Assessment of Techniques for Protein Structure Prediction. For the first time, aggressive sampling and all-atom refinement could be carried out for the majority of targets, an advance enabled(More)
An assembly of systemic and metabolic changes that occur within 90 minutes after the onset of a systemic inflammatory reaction is termed as acute phase reaction/response. This is caused due to the change in the concentrations (increase/decrease) of a class of proteins called as acute phase proteins. In periodontitis, subgingival gram negative bacteria(More)
Periodontal disease is characterized by inflammation and/or destruction of supporting tissue of the teeth. Bacterial plaque is the primary etiological agent in periodontal diseases. In addition to mechanical plaque removal measures, chemical plaque control measures have also been advocated that can be used as an adjunct to mechanical measures, which(More)
CONTEXT Platelet-rich-plasma (PRP) and Platelet-rich-fibrin (PRF) are extensively used autologous platelet concentrates in periodontal regeneration, and PRF has a better efficacy as compared to PRP. The rationale for this difference has often been attributed to the difference in the structure of the fibrin matrix. However, the effect of concentration of(More)
CONTEXT Periodontal disease and diabetes mellitus(DM) share a two - way relationship. It can be hypothesized that successful management of periodontal infection in diabetes will lead not only to reduction of local signs and symptoms of the disease, but also to better control of glucose metabolism. AIMS To monitor the effect of Scaling and Root planing(More)
Structure prediction for CASP7 targets using extensive all-atom refinement with Rosetta@home Rhiju Das, Bin Qian, Srivatsan Raman, Robert Vernon, James Thompson, Philip Bradley, Sagar Khare, Michael D. Tyka, Divya Bhat, Dylan Chivian, David E. Kim, William H. Sheffler, Lars Malmström, Andrew M. Wollacott, Chu Wang, Ingemar Andre, and David Baker*(More)
An Endo perio lesion has been one of the most common problems associated with the tooth. The simultaneous involvement of pulpal problems and inflammatory periodontal disease can complicate diagnosis and treatment planning. The present case report shows the importance of periodontal therapy that includes open debridement of the defect followed by placement(More)
CONTEXT Antimicrobial proteins and peptides constitute a diverse class of host-defense molecules that act early to combat invasion and infection with bacteria and other microorganisms. Among the various antimicrobial peptides in the oral cavity, adrenomedullin (ADM), a cationic peptide, is found in gingival crevicular fluids (GCFs) in amounts twice as high(More)
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