Ditlev Egeskov Brodersen

Kasper Røjkjær Andersen1
Patricia Romans-Fuertes1
Just Justesen1
1Kasper Røjkjær Andersen
1Patricia Romans-Fuertes
1Just Justesen
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The vertebrate 2-5A system is part of the innate immune system and central to cellular antiviral defense. Upon activation by viral double-stranded RNA, 5'-triphosphorylated, 2'-5'-linked oligoadenylate polyribonucleotides (2-5As) are synthesized by one of several 2'-5'-oligoadenylate synthetases. These unusual oligonucleotides activate RNase L, an(More)
  • Patricia Romans-Fuertes, Teis Esben Sondergaard, Manuela Ilse Helga Sandmann, Rasmus Dam Wollenberg, Kristian Fog Nielsen, Frederik T. Hansen +3 others
  • 2016
Sansalvamide is a cyclic pentadepsipeptide produced by Fusarium solani and has shown promising results as potential anti-cancer drug. The biosynthetic pathway has until now remained unidentified, but here we used an Agrobacterium tumefaciens-mediated transformation (ATMT) approach to generate knockout mutants of two candidate non-ribosomal peptide(More)
MOTIVATION By using a class of large modular enzymes known as Non-Ribosomal Peptide Synthetases (NRPS), bacteria and fungi are capable of synthesizing a large variety of secondary metabolites, many of which are bioactive and have potential, pharmaceutical applications as e.g. antibiotics. There is thus an interest in predicting the compound synthesized by(More)
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