Dirkjan van Schaardenburg

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The aims of this study were to describe rheumatoid arthritis patients’ compliance with continued exercise after participation in a 2-year supervised high-intensity exercise program and to investigate if the initially achieved effectiveness and safety were sustained. Data were gathered by follow-up of the participants who completed the 2-year high-intensity(More)
OBJECTIVE To evaluate the prevalence and 8-year course of forefoot impairments and walking disability in patients with rheumatoid arthritis (RA). METHODS A total of 848 patients with recent-onset RA from 1995 through the present were included. The patients were assessed annually. Pain and swelling of the metatarsophalangeal (MTP) joints, erosions and(More)
Objective Recently, we discovered a new autoantibody system in rheumatoid arthritis (RA): anti-carbamylated protein antibodies (anti-CarP). These antibodies have prognostic value in predicting joint destruction. However, it is not clear whether they are present before the diagnosis of RA and whether they have predictive value for the development of RA.(More)
BACKGROUND Workers with rheumatoid arthritis (RA) often experience restrictions in functioning at work and participation in employment. Strategies to maintain work productivity exist, but these interventions do not involve the actual workplace. Therefore the aim of this study is to investigate the (cost)effectiveness of an intervention program at the(More)
Background During the transition to rheumatoid arthritis (RA) many patients pass through a phase characterised by the presence of symptoms without clinically apparent synovitis. These symptoms are not well-characterised. This taskforce aimed to define the clinical characteristics of patients with arthralgia who are considered at risk for RA by experts based(More)
Several advances have been made in the understanding of the pathogenesis, as well as in the clinical evaluation and treatment, of early inflammatory arthritis. The presence of anti-citrullinated protein antibodies (ACPAs) has emerged as a major new biomarker for use in clinical practice. The presence of ACPAs can be used to divide patients with early(More)
Objective—To assess the cost eVectiveness of antibiotic prophylaxis for haematogenous bacterial arthritis in patients with joint disease. Methods—In a decision analysis, data from a prospective study on bacterial arthritis in 4907 patients with joint disease were combined with literature data to assess risks and benefits of antibiotic prophylaxis.(More)
Objectives To validate the presence and demonstrate the clinical value of the type I interferon (IFN)-signature during arthritis development. Method In 115 seropositive arthralgia patients who were followed for the development of arthritis (Amsterdam Reade cohort), and 25 pre-symptomatic individuals who developed RA later and 45 population-based controls(More)
Objective—To assess the cost eVectiveness of antibiotic prophylaxis for haematogenous bacterial arthritis in patients with joint disease. Methods—In a decision analysis, data from a prospective study on bacterial arthritis in 4907 patients with joint disease were combined with literature data to assess risks and benefits of antibiotic prophylaxis.(More)
Background: The anti-cyclic citrullinated peptide (CCP) test has a high sensitivity and specificity for rheumatoid arthritis, although CCP is not the physiological target of the autoantibodies. Citrullinated fibrin is abundant in inflamed synovium Objective: To assess the diagnostic and prognostic value of antibodies against citrullinated fibrinogen (ACF),(More)