Learn More
Near-infrared spectrometry (NIR) was used to quantify metroprolol succinate in controlled release tablets. Metoprolol tablets were made according to an experimental design using different strengths around a central strength of 47.5 mg per tablet. A comparison was made between NIR in the diffuse reflectance mode and the transmission mode. This showed that,(More)
In this paper, the authors discuss an instrument for the assessment of enterprise coherence (Enterprise Coherence Assessment, ECA). The term ‘coherence’ is used rather than the more common term ‘alignment’, since the latter is generally associated with bringing two concepts in line (typically ‘Business’ and ‘IT’). The word coherence, however, stresses the(More)
Real time release (RTR) of products is a new paradigm in the pharmaceutical industry. An RTR system assures that when the last manufacturing step is passed all the final release criteria are met. Various types of models can be used within the RTR framework. For each RTR system, the monitoring capability, control capability and RTR capability need to be(More)
In this review we describe the impact of chirality on drug development and registration in the United States, Japan and the European Community. Enantiomers may have differences in their pharmacological profiles, and, therefore, chiral drugs ask for special analytical and pharmacological attention during their development. However, the registration(More)
Net analyte signal statistical quality control (NAS-SQC) is a new methodology to perform multivariate product quality monitoring based on the net analyte signal approach. The main advantage of NAS-SQC is that the systematic variation in the product due to the analyte (or property) of interest is separated from the remaining systematic variation due to all(More)
The Enterprise Coherence-governance Assessment (ECA) instrument is a part of the GEA (General Enterprise Architecting) method for enterprise architecture. Based on experiences with this assessment instrument in a range of real world projects, the ECA has been improved, leading to the extended Enterprise Coherence-governance Assessment (eECA). So far, the(More)
This paper is concerned with a real world case study in Business/IT alignment at the strategic level. The case study is situated in the Dutch public sector, involving the Ministry of Social Affairs and Employment (SAE). In this case study, the GEA (Generic Enterprise Architecting) method was used. This paper will therefore take the GEA method as a given.(More)
This paper is concerned with an application of the GEA (General Enterprise Architecting) method in the Dutch public sector, in particular at the Custodial Institutions Agency (Dienst Justitieële Inrichtingen, DJI), an agency of the Ministry of Security and Justice. The DJI is, on behalf of the Minister of Security and Justice, responsible for the(More)
In this paper we are not so much concerned with enterprise architecture as a product or process, but rather with the competencies of the professionals who are responsible for the creation of an enterprise architecture, i.e. the enterprise architects themselves. We present the integrated result of three surveys held in the Netherlands, on the competencies(More)